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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
826 stopped studies mapped to Malignant Female Reproductive System Neoplasm and descendants · 86% state a reason
Over the 826 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT02567396 | Talazoparib in Treating Patients With Advanced or Metastatic Solid Tumors That Cannot Be… | Phase 1 | withdrawn | Oct 5, 2015 | National Cancer Institute (NCI) | Other- Protocol moved to Disapproved | Other (stated, no rule matched) |
| NCT01138137 | N-acetylcysteine Given IV With Cisplatin and Paclitaxel in Patients With Ovarian Cancer | Phase 1 | withdrawn | Jun 7, 2010 | OHSU Knight Cancer Institute | No funding was available for the cost of the IV N-acetylcysteine (NAC). | Funding |
| NCT02633254 | Targeted Vessel Ablation of Type 3 Uterine Fibroids With Magnetic Resonance Guided High… | N/A | terminated | Dec 17, 2015 | UMC Utrecht | not stated | Not stated |
| NCT01504308 | Sonalleve Fibroid Ablation Pivotal Clinical Trial for MR-HIFU of Uterine Fibroids(SOFIA) | Phase 2 / Phase 3 | terminated | Jan 5, 2012 | Philips Healthcare | It was not possible to enroll patients into the study in a realistic timeframe. | Enrollment / accrual |
| NCT02067637 | Delayed Effects of Treatment in Cancer Survivors (DETECS)(DETECS) | — | withdrawn | Feb 20, 2014 | University of Colorado, Denver | Low accrual | Enrollment / accrual |
| NCT00738699 | An Efficacy and Safety Study of MORAb-003 in Platinum-Resistant or Refractory Relapsed…(FAR-122) | Phase 2 | terminated | Aug 20, 2008 | Morphotek | study did not meet pre-specified criteria for continuation following interim futility analysis | Efficacy / futility |
| NCT02218502 | Study Into a New Diagnostic Tool (Simple Ultrasound-based Rules) in Patients With Adnexal…(SUBSONiC) | N/A | terminated | Aug 18, 2014 | Maastricht University Medical Center | interim analysis showed incorrect use of simple rules | Efficacy / futility |
| NCT01659554 | A Phase II Combined Modality Protocol of Debulking Surgery With HIPEC Followed by…(HIPEC) | Phase 2 | terminated | Aug 8, 2012 | Columbia University | Principal Investigator left institution | Investigator |
| NCT00883116 | A Study of Ixabepilone as Second-line Therapy for Locally Advanced, Recurrent, or…(IXAMPLE2) | Phase 3 | terminated | Apr 17, 2009 | R-Pharm | Interim analysis results showed that ixabepilone did not improve survival compared with control… | Efficacy / futility |
| NCT01137071 | Consolidation Therapy With Hu3S193 for Women With Ovarian, Primary Peritoneal or… | Phase 2 | terminated | Jun 4, 2010 | Recepta Biopharma | Total number of pts expected to be enrolled would not be met. | Enrollment / accrual |
| NCT01493505 | TRINOVA-3: A Study of AMG 386 or AMG 386 Placebo in Combination With Paclitaxel and… | Phase 3 | terminated | Dec 16, 2011 | Amgen | Amgen Administrative Decision - termination of LTFU | Other (stated, no rule matched) |
| NCT00946283 | Lactobacillus in Preventing Infection in Patients Undergoing a Donor Stem Cell Transplant… | N/A | terminated | Jul 24, 2009 | Rutgers, The State University of New Jersey | slow accrual | Enrollment / accrual |
| NCT00629577 | Gene Expression Profiling of Cervical Cancer Progression in Biopsies and Tissue Samples(SAGE) | Phase 1 | terminated | Mar 6, 2008 | British Columbia Cancer Agency | no funding | Funding |
| NCT00584909 | A Phase II Study of Paclitaxel and Carboplatin in Patients With an Elevated-Risk Cancer… | Phase 2 | terminated | Jan 2, 2008 | University of Alabama at Birmingham | low accrual | Enrollment / accrual |
| NCT01971060 | a Study to Evaluate Adhesion Risk in Fertility Patients' Status Post Laparoscopic…(VLocmyo) | N/A | withdrawn | Oct 28, 2013 | The Advanced Gynecologic Surgery Institute | lack of funding | Funding |
| NCT00550654 | Conformal Radiation Therapy in Treating Patients With Metastatic Cancer Outside the Brain | Phase 2 | terminated | Oct 30, 2007 | National Institutes of Health Clinical Center (CC) | Study was terminated due to poor accrual. | Enrollment / accrual |
| NCT00452920 | Docetaxel and Radiation Therapy in Treating Patients With Stage II, Stage III, or Stage… | Phase 1 / Phase 2 | withdrawn | Mar 28, 2007 | University of Miami | not stated | Not stated |
| NCT01521143 | Cvac as Maintenance Treatment in Patients With Epithelial Ovarian Cancer in Complete…(CANVAS) | Phase 2 | terminated | Jan 30, 2012 | Prima BioMed Ltd | The study was terminated due to company restructuring and changes in drug development priorities. | Sponsor / business decision |
| NCT02035345 | Slowed Carboplatin Infusion for Ovarian Cancer Patients Receiving Carboplatin Re-Treatment | Phase 4 | terminated | Jan 14, 2014 | Massachusetts General Hospital | Extended Carboplatin Infusion did not Reduce Frequency of Hypersensitivity Reactions | Other (stated, no rule matched) |
| NCT00637390 | A Phase I Study of Alemtuzumab in Patients With Relapsed Ovarian/Primary Peritoneal… | Phase 1 | terminated | Mar 18, 2008 | University of Michigan Rogel Cancer Center | Genzyme will no longer supply the study drug for this trial as it does not believe the study will… | Drug supply |
| NCT01061606 | Temsirolimus in Treating Patients With Recurrent or Persistent Cancer of the Uterus | Phase 2 | terminated | Feb 3, 2010 | National Cancer Institute (NCI) | Poor accrual | Enrollment / accrual |
| NCT00842582 | Azacitidine With Carboplatin and Paclitaxel for Newly Diagnosed Ovarian Cancer | Phase 1 | withdrawn | Feb 12, 2009 | Loyola University | No enrollment. Unable to recruit due to lack of eligible patients. | Enrollment / accrual |
| NCT01227941 | MK-4827 in Combination With Pegylated Liposomal Doxorubicin in Participants With Advanced… | Phase 1 | terminated | Oct 25, 2010 | Tesaro, Inc. | not stated | Not stated |
| NCT02667925 | Study of the Isotopic Distribution of Intraperitoneal Chemotherapy for Peritoneal…(ISOTOVE) | N/A | withdrawn | Jan 29, 2016 | Centre Jean Perrin | Because of the obsolescence of the study | Other (stated, no rule matched) |
| NCT00862836 | Addition of Vandetanib to Standard Therapy Pegliposomal Doxorubicin (PLD)(ZACFAST) | Phase 1 / Phase 2 | terminated | Mar 17, 2009 | Genzyme, a Sanofi Company | Lack of efficacy | Efficacy / futility |
| NCT01032447 | Overcoming Obstacles to Clinical Trials Enrollment Through a Navigator Program | — | terminated | Dec 15, 2009 | Stanford University | not stated | Not stated |
| NCT02042495 | Endometrial Cancer Biomarker Changes Following Exposure to Metformin | Phase 2 | withdrawn | Jan 23, 2014 | Jewish General Hospital | Did not obtain Health Canda approval for drug use in reasonable time and moved onward to new trial | Other (stated, no rule matched) |
| NCT00590967 | A Phase II Study of Extended Field IMRT External Beam Irradiation and Intracavitary… | Phase 2 | terminated | Jan 11, 2008 | Washington University School of Medicine | Due to low accrual | Enrollment / accrual |
| NCT02469116 | Carboplatin Plus Docetaxel With Day 2 Pegylated G-CSF (Neulasta®) in Patients With… | Phase 2 | terminated | Jun 11, 2015 | Washington University School of Medicine | Sponsor withdrew financial support | Funding |
| NCT02348398 | Phase II Study of Pazopanib and Topotecan in Cervical Cancer | Phase 2 | withdrawn | Jan 28, 2015 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT02083536 | LDFWART With Docetaxel in Patients With Platinum-Resistant Recurrent Ovarian Carcinoma | Phase 1 | withdrawn | Mar 11, 2014 | University of Miami | Study voluntarily stopped by Principal Investigator due to lack of accrual. | Investigator |
| NCT01555073 | Preemptive Analgesia Following Uterine Artery Embolization | Phase 4 | terminated | Mar 15, 2012 | Northwestern University | Subjects did not meet inclusion criteria | Other (stated, no rule matched) |
| NCT02627430 | Talazoparib and HSP90 Inhibitor AT13387 in Treating Patients With Metastatic Advanced… | Phase 1 | withdrawn | Dec 11, 2015 | National Cancer Institute (NCI) | Other - Protocol moved to Withdrawn | Other (stated, no rule matched) |
| NCT01003938 | Topotecan With Erlotinib for Topotecan Pretreated Ovarian Cancer | Phase 2 | terminated | Oct 29, 2009 | NYU Langone Health | due to administrative issue and financial sponsor decision to suspend ovarian cancer studies | Funding |
| NCT00003852 | Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients… | Phase 2 | terminated | Jan 27, 2004 | UNICANCER | lack of patient inclusion | Other (stated, no rule matched) |
| NCT00671606 | Hysteroscopic Lymphatic Mapping for Endometrial Cancer | Phase 2 | terminated | May 5, 2008 | M.D. Anderson Cancer Center | Slow accrual. | Enrollment / accrual |
| NCT01356329 | Efficacy and Safety of the LovenoxTM (Enoxaparin) Versus HeparinTM Gynecologic Oncology…(Lovenox) | Phase 3 | suspended | May 19, 2011 | National Guard Health Affairs | Difficulty in enrolling patients | Enrollment / accrual |
| NCT00529464 | Spectroscopy Versus Standard Care in Cervical Cancer Patients | Phase 3 | terminated | Sep 14, 2007 | M.D. Anderson Cancer Center | Two participants enrolled, both inevaluable. | Enrollment / accrual |
| NCT00634894 | Femara (Letrozole) Versus Placebo for Patients With Ovarian, Fallopian Tube, or Primary… | Phase 2 | withdrawn | Mar 13, 2008 | M.D. Anderson Cancer Center | Study halted with no registration, the drug company sponsor withdrew support. | Sponsor / business decision |
| NCT02479178 | A Study of BIND-014 in Patients With Urothelial Carcinoma, Cholangiocarcinoma, Cervical…(iNSITE2) | Phase 2 | terminated | Jun 24, 2015 | BIND Therapeutics | not stated | Not stated |
| NCT01675011 | Embozene Microspheres for Uterine Fibroid Embolization (UFE) | N/A | terminated | Aug 29, 2012 | Boston Scientific Corporation | Inadequate enrollment | Enrollment / accrual |
| NCT00526799 | Sorafenib + Topotecan for Platinum-Resistant Recurrent Ovarian Cancer | Phase 1 / Phase 2 | terminated | Sep 10, 2007 | Daniela Matei, MD | Study closed to accrual due unfavorable interim analysis | Efficacy / futility |
| NCT00522301 | Sorafenib in Treating Patients With Ovarian Epithelial Cancer, Fallopian Tube Cancer, or… | Phase 2 | terminated | Aug 29, 2007 | Memorial Sloan Kettering Cancer Center | not stated | Not stated |
| NCT01514955 | An Initial Feasibility Study to Integrate MRI Based Brachytherapy and CT/MR Fused INRT in…(IMRT) | Phase 1 | withdrawn | Jan 23, 2012 | AHS Cancer Control Alberta | not stated | Not stated |
| NCT02470559 | Activated T-cell Therapy, Low-Dose Aldesleukin, and Sargramostim in Treating Patients… | Phase 1 | withdrawn | Jun 12, 2015 | Barbara Ann Karmanos Cancer Institute | Study did not accrue any participants, the PI has left the institution. | Enrollment / accrual |
| NCT01624493 | BNC105P Combination Study in Partially Platinum Sensitive Ovarian Cancer Patients | Phase 1 / Phase 2 | withdrawn | Jun 20, 2012 | Hoosier Cancer Research Network | Phase I was conducted Australia. Phase II not conducted and no US pts enrolled. | Enrollment / accrual |
| NCT01840943 | A Study to Compare CAELYX With Topotecan HCL in Patients With Recurrent Epithelial… | Phase 3 | terminated | Apr 26, 2013 | Xian-Janssen Pharmaceutical Ltd. | the study was terminated due to medication supply issue from current manufacturer | Drug supply |
| NCT00313612 | Oxaliplatin and Topotecan in Advance Ovarian Cancer | Phase 2 | terminated | Apr 12, 2006 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00596544 | Sexual Functioning After Primary Treatment of Ovarian Cancer | — | terminated | Jan 17, 2008 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT02042885 | A Clinical Trial to Determine the Most Suitable Dose of OPB-111001 in Patients With… | Phase 1 / Phase 2 | terminated | Jan 23, 2014 | Otsuka Novel Products GmbH | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Apr 24, 2017source: clinicaltrials