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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
2,225 stopped studies mapped to Malignant Digestive System Neoplasm and descendants · 91% state a reason
Over the 2,225 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00457327 | Pilot Study for Evaluation of the Need for Protective Ileostomy After Low Anterior… | Phase 2 | terminated | Apr 6, 2007 | Heidelberg University | RCT with same hypothesis ended and showed a superiority for protective ileostomy after lower… | Other (stated, no rule matched) |
| NCT00358566 | GV1001 and Gemcitabine in Sequential Combination to Gemcitabine Monotherapy in Pancreatic… | Phase 3 | terminated | Aug 1, 2006 | Pharmexa A/S | Preliminary data showed no survival benefit in the GV1001 group compared to the gemcitabine group. | Other (stated, no rule matched) |
| NCT00443573 | Safety Study of Recombinant NAPc2 to Prevent Tumor Progression and Metastases in… | Phase 1 / Phase 2 | suspended | Mar 6, 2007 | ARCA Biopharma, Inc. | Company suspended development of product. | Sponsor / business decision |
| NCT00440934 | A Study of Electromagnetic Waves in the Treatment of the Advanced Hepatocarcinoma(THBC002) | Phase 2 | terminated | Feb 27, 2007 | Pasche, Boris, M.D. | Poor patient accrual | Enrollment / accrual |
| NCT00176787 | Radiation Therapy With Capecitabine in Rectal Cancer | Phase 2 | terminated | Sep 15, 2005 | University of Michigan Rogel Cancer Center | recruitment goals met | Enrollment / accrual |
| NCT00346099 | Study of Panitumumab Given First With Capecitabine and Oxaliplatin (CAPOX) and Then With… | Phase 2 | withdrawn | Jun 29, 2006 | NSABP Foundation Inc | Protocol closed based on new (and as yet unpublished) information from a phase II clinical trial. | Other (stated, no rule matched) |
| NCT00121745 | Evaluation of Safety of Rexin-G Gene Transfer for Advanced Pancreatic Cancer | Phase 1 | terminated | Jul 21, 2005 | Epeius Biotechnologies | poor enrollment | Enrollment / accrual |
| NCT00120172 | Study of Oxaliplatin, Capecitabine, and Bevacizumab to Treat Older Patients With… | Phase 2 | terminated | Jul 15, 2005 | Geriatric Oncology Consortium | positive results from a larger study with same regimen was released. | Other (stated, no rule matched) |
| NCT00216424 | Capecitabine (Xeloda) and Radiation for Patients With Rectosigmoid Carcinoma | Phase 4 | terminated | Sep 22, 2005 | James A. Haley Veterans Administration Hospital | lack of accrual | Enrollment / accrual |
| NCT00216437 | Dose Escalation Study Combining Oral Capecitabine (Xeloda) and Radiotherapy for Patients… | Phase 1 | terminated | Sep 22, 2005 | James A. Haley Veterans Administration Hospital | lack of accrual | Enrollment / accrual |
| NCT00536770 | A Study of Gemcitabine ± Erlotinib and DN-101 Versus Gemcitabine ± Erlotinib and Placebo… | Phase 2 | suspended | Sep 28, 2007 | Novacea | DSMB | Other (stated, no rule matched) |
| NCT00209677 | Phase I/II Study of Oral S-1 Plus Gemcitabine in Patients With Metastatic Pancreatic… | Phase 1 / Phase 2 | suspended | Sep 21, 2005 | Hokkaido Gastrointestinal Cancer Study Group | Unfortunately, other Phase III clinical Study (GEM+S-1 vs GEM vs S-1) have been started in Japan. h | Other (stated, no rule matched) |
| NCT00316745 | IRIS Followed by mFOLFOX6 or the Reverse Sequence in Advanced Colorectal Cancer | Phase 3 | suspended | Apr 21, 2006 | Hokkaido Gastrointestinal Cancer Study Group | Because of approval of Bevacizumab, it was difficult to perform clinical study in 1st line setting. | Other (stated, no rule matched) |
| NCT00514332 | Comparison Between Colorectal Stents and Primary Surgery in Obstructive Colonic Cancer. A… | N/A | terminated | Aug 9, 2007 | University Hospital, Montpellier | enrolling participants stopped | Enrollment / accrual |
| NCT00116389 | Trial of Talabostat and Gemcitabine in Patients With Stage IV Adenocarcinoma of the… | Phase 2 | terminated | Jun 29, 2005 | Point Therapeutics | FDA Hold May 2007 | Other (stated, no rule matched) |
| NCT00229567 | Intra-op Lidocaine and Ketamine Effect on Postoperative Bowel Function | N/A | terminated | Sep 29, 2005 | University of Saskatchewan | insufficient numbers of eligible patients as laparscopic surgery increased and open surgery… | Other (stated, no rule matched) |
| NCT00176761 | Tumor-Pulsed Dendritic Cells Used as a Tumor Vaccine | Phase 2 | terminated | Sep 15, 2005 | University of Michigan Rogel Cancer Center | not stated | Not stated |
| NCT00355212 | Comparison Between Radiofrequency Versus Ethanol Injection for the Treatment of… | Phase 3 | terminated | Jul 21, 2006 | Azienda Ospedaliera San Giovanni Battista | not stated | Not stated |
| NCT00114946 | A Study to Compare Two Avastin-Based Treatment Regimens for the Treatment of Metastatic… | Phase 4 | terminated | Jun 21, 2005 | Genentech, Inc. | not stated | Not stated |
| NCT00209703 | Feasibility Study of mFOLFOX6 in Patients With Advanced Colorectal Cancer | Phase 2 | terminated | Sep 21, 2005 | Hokkaido Gastrointestinal Cancer Study Group | not stated | Not stated |
| NCT00209664 | Phase II Study of Oral S-1 Plus Irinotecan in Patients With Advanced Gastric Cancer | Phase 2 | suspended | Sep 21, 2005 | Hokkaido Gastrointestinal Cancer Study Group | not stated | Not stated |
| NCT00179751 | A Phase I/II Study of Lenalidomide in Combination With Gemcitabine in Patients With… | Phase 1 / Phase 2 | terminated | Sep 16, 2005 | Celgene Corporation | not stated | Not stated |
| NCT00034333 | Safety and Efficacy of Doxorubicin Adsorbed to Magnetic Beads Vs. IV Doxorubicin in… | Phase 2 / Phase 3 | terminated | Apr 26, 2002 | FeRx | not stated | Not stated |
| NCT00048529 | Study of T900607-Sodium in Subjects With Previously Treated Gastric Cancer or… | Phase 2 | suspended | Nov 4, 2002 | Tularik | not stated | Not stated |
| NCT00057382 | T138067 Versus Doxorubicin in Chemotherapy-Naive, Unresectable, Hepatocellular Carcinoma… | Phase 2 / Phase 3 | terminated | Apr 2, 2003 | Tularik | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 22 days agoSource updated Jun 5, 2008source: clinicaltrials