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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
2,225 stopped studies mapped to Malignant Digestive System Neoplasm and descendants · 91% state a reason
Over the 2,225 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00618384 | TACE and Sorafenib for Advanced Hepatocellular Carcinoma (HCC)(SOCRATES) | Phase 2 | terminated | Feb 20, 2008 | Heinrich-Heine University, Duesseldorf | not stated | Not stated |
| NCT01056809 | Treatment Strategies for Primarily Generalized Colorectal Cancer(PGC) | N/A | terminated | Jan 26, 2010 | Vrinnevi Hospital | Too slow recruitment | Enrollment / accrual |
| NCT01031056 | Collection of Biospecimen & Clinical Information in Patients w/ Gastrointestinal Cancers | — | withdrawn | Dec 14, 2009 | Stanford University | Change in research focus | Other (stated, no rule matched) |
| NCT00006269 | Octreotide in the Prevention of Diarrhea in Patients Receiving Irinotecan for Metastatic… | Phase 3 | terminated | May 24, 2004 | Novartis | not stated | Not stated |
| NCT00767468 | Sorafenib in Treating Patients With Locally Advanced or Metastatic Liver Cancer and… | Phase 1 | terminated | Oct 7, 2008 | UNC Lineberger Comprehensive Cancer Center | Funding unavailable | Funding |
| NCT01203163 | Case Analysis on Real Life Incidence of Photodynamic Therapy (PDT) Safety Outcomes(CALIPSO) | — | withdrawn | Sep 16, 2010 | Pinnacle Biologics Inc. | Sponsor cancelled the study | Other (stated, no rule matched) |
| NCT00824161 | Phase II Study of TAS-109 to Treat Advanced Colorectal Cancer | Phase 2 | terminated | Jan 16, 2009 | Taiho Pharmaceutical Co., Ltd. | not stated | Not stated |
| NCT01109615 | Pemetrexed and Gemcitabine for Treatment Resistant Patients With Metastatic Colorectal…(PG) | Phase 2 | terminated | Apr 23, 2010 | Vejle Hospital | Lacking effect of treatment | Other (stated, no rule matched) |
| NCT01194206 | Stereotactic Body Radiation Therapy in Liver Cancer That Cannot be Removed by Surgery or… | Phase 2 | withdrawn | Sep 2, 2010 | Case Comprehensive Cancer Center | Study being rewritten | Other (stated, no rule matched) |
| NCT01196000 | Laparoscopic Surgery or Robotic-Assisted Laparoscopic Surgery in Treating Patients With… | N/A | withdrawn | Sep 8, 2010 | City of Hope Medical Center | The study has never been opened to accrual at COH. Study to be closed at COH due to the lack of… | Enrollment / accrual |
| NCT00495625 | Sunitinib Malate (SUO11248) In Subjects W/ Metastatic And/Or Surgically Unresectable… | Phase 2 | terminated | Jul 3, 2007 | H. Lee Moffitt Cancer Center and Research Institute | not stated | Not stated |
| NCT00503932 | Proton Therapy With Capecitabine for Rectal Cancer | Phase 1 / Phase 2 | withdrawn | Jul 19, 2007 | M.D. Anderson Cancer Center | No participant enrollment. | Enrollment / accrual |
| NCT01337492 | Pilot Study Sorafenib as Bridge to Orthotopic Liver Transplantation (OLT) | Early Phase 1 | terminated | Apr 19, 2011 | Case Comprehensive Cancer Center | slow accrual | Enrollment / accrual |
| NCT00873002 | Panobinostat and Sorafenib in Treating Patients With Liver Cancer That is Metastatic… | Phase 1 | terminated | Apr 1, 2009 | Case Comprehensive Cancer Center | Dose Limiting Toxicity | Safety / toxicity |
| NCT01126450 | Lenalidomide and Cetuximab in Treating Patients With Metastatic Colorectal Cancer | Phase 1 | terminated | May 19, 2010 | Case Comprehensive Cancer Center | low accrual,loss of funding and results from EU study showing drug ineffective. | Enrollment / accrual |
| NCT00137683 | Colorectal Cancer Control in Appalachian Churches | Phase 2 / Phase 3 | withdrawn | Aug 30, 2005 | Centers for Disease Control and Prevention | not stated | Not stated |
| NCT00110721 | GM-CT-01 Plus 5-Fluorouracil as Third- or Fourth-Line Therapy for Metastatic Colorectal… | Phase 2 | terminated | May 13, 2005 | Galectin Therapeutics Inc. | Study protocol amended to a new treatment regimen: study DAVFU-006. | Other (stated, no rule matched) |
| NCT00429078 | Trial of 2nd Generation Anti-CEA Designer T Cells in Gastric Cancer | Phase 1 | withdrawn | Jan 31, 2007 | Roger Williams Medical Center | low accrual | Enrollment / accrual |
| NCT00532987 | Assessment of Health Related Quality of Life in Patients Treated for Rectal Cancer | — | terminated | Sep 21, 2007 | Stanford University | not stated | Not stated |
| NCT00831493 | Vorinostat Plus Radiation Therapy in Pancreatic Cancer | Phase 1 / Phase 2 | terminated | Jan 29, 2009 | M.D. Anderson Cancer Center | Slow Accrual. | Enrollment / accrual |
| NCT01212887 | Treated Blood Cells, Cyclophosphamide, Fludarabine Phosphate, and Aldesleukin in Treating… | Phase 1 | terminated | Oct 1, 2010 | Cancer Research UK | due to safety concerns and lack of efficacy | Safety / toxicity |
| NCT00151671 | Effect of a Perioperative Oral Nutritional Supplementation on Patients Undergoing Hepatic…(IMPACT) | Phase 2 / Phase 3 | terminated | Sep 9, 2005 | Rennes University Hospital | insufficient enrollment rate | Enrollment / accrual |
| NCT01096381 | Potential Biomarkers for Bevacizumab-Induced High Blood Pressure in Patients With Solid… | — | terminated | Mar 31, 2010 | Vanderbilt-Ingram Cancer Center | funding withdrawn due to fellow's departure from VICC | Funding |
| NCT00585741 | Pilot Study of 18F-FLT PET | N/A | terminated | Jan 3, 2008 | University of Wisconsin, Madison | not stated | Not stated |
| NCT00003714 | Chemotherapy in Treating Patients With Unresectable Primary or Metastatic Kidney Cancer | Phase 2 | withdrawn | Sep 14, 2004 | M.D. Anderson Cancer Center | Withdrawn | Other (stated, no rule matched) |
| NCT01318200 | Transarterial Chemoembolization (TACE) vs. CyberKnife for Recurrent Hepatocellular… | Phase 3 | withdrawn | Mar 18, 2011 | Accuray Incorporated | not stated | Not stated |
| NCT00609310 | Dietary Bioflavonoid Supplementation for the Prevention of Neoplasia Recurrence | Phase 2 | suspended | Feb 7, 2008 | Technische Universität Dresden | not stated | Not stated |
| NCT00768001 | Genetic Analysis of Liver Cancer | — | terminated | Oct 7, 2008 | Samuel So | low accrual | Enrollment / accrual |
| NCT00967291 | Mitomycin C and Ifosfamide in Treating Patients With Metastatic Pancreatic Cancer(PACT-11) | Phase 2 | terminated | Aug 27, 2009 | IRCCS San Raffaele | lack of activity and G3-4 toxicity at interim analysis | Safety / toxicity |
| NCT00969033 | CS-1008 Used With Irinotecan Versus Irinotecan Alone in Subjects With Metastatic… | Phase 2 | terminated | Aug 31, 2009 | Daiichi Sankyo | not stated | Not stated |
| NCT00296062 | Dose Dense Therapy and Bevacizumab in Solid Tumors and Colorectal Cancer | Phase 1 | terminated | Feb 24, 2006 | Case Comprehensive Cancer Center | Trial did not move to Phase II portion due to poor tolerance of treatment | Other (stated, no rule matched) |
| NCT01441388 | A Study Of Crizotinib Plus VEGF Inhibitor Combinations In Patients With Advanced Solid… | Phase 1 | withdrawn | Sep 27, 2011 | Pfizer | Business/Operational issues | Sponsor / business decision |
| NCT00860249 | Outreach for Patients That Are Newly Eligible for Colorectal Cancer Screening(UPQUAL) | N/A | terminated | Mar 12, 2009 | Northwestern University | Lack of sufficient participants meeting the eligibility criteria to complete study in proposed and… | Other (stated, no rule matched) |
| NCT01175291 | FOLFOX/Bevacizumab +/- MK-0646 in Metastatic Colorectal Cancer | Phase 2 | withdrawn | Aug 4, 2010 | H. Lee Moffitt Cancer Center and Research Institute | treatment deemed ineffective so accrual was closed | Enrollment / accrual |
| NCT00593008 | Temsirolimus in Combination With Gemcitabine in Previously Untreated Metastatic… | Phase 1 | terminated | Jan 14, 2008 | Massachusetts General Hospital | not stated | Not stated |
| NCT01245582 | Oxaliplatin and Capecitabine on Top of Sorafenib Versus Sorafenib Alone in Advanced…(SECOX) | Phase 3 | withdrawn | Nov 22, 2010 | Sanofi | not stated | Not stated |
| NCT00779311 | A Phase I Trial Evaluating mFOLFOX6 and Avastin With Nexavar as First-Line Treatment for… | Phase 1 | terminated | Oct 24, 2008 | Accelerated Community Oncology Research Network | Dose limiting toxicity at the lowest planned dose level. | Safety / toxicity |
| NCT00225290 | Phase III Trial of Oral Thalidomide in Advanced Hepatocellular Carcinoma With Poor Liver… | Phase 3 | terminated | Sep 23, 2005 | TTY Biopharm | slowly recruitment rate | Enrollment / accrual |
| NCT00281996 | Imatinib Mesylate and Gemcitabine in Treating Patients With Locally Advanced, Metastatic,… | Phase 1 | terminated | Jan 25, 2006 | Northwestern University | Closed to accrual to allow enrollment on another more promising trial. | Enrollment / accrual |
| NCT00732745 | Vandetanib, Oxaliplatin, and Docetaxel in Advanced Cancer of the Esophagus or… | Phase 1 | terminated | Aug 12, 2008 | Case Comprehensive Cancer Center | Lost funding for Phase II portion of study | Funding |
| NCT00683085 | Human Leukocyte Antigen-A*02:01-restricted Tumor Vessel Specific Peptide Vaccination for… | Phase 1 / Phase 2 | terminated | May 23, 2008 | Tokyo University | Lack of eligible patient | Other (stated, no rule matched) |
| NCT00725400 | Comparative Study of Cetuximab and Radiation Vs Surgery Before or After Radiation in… | Phase 2 | withdrawn | Jul 30, 2008 | American Scitech International | Study is withdrawn due to unavailability of eligible subject population. We will request the… | Enrollment / accrual |
| NCT00898781 | Study of Circulating Cancer Cells in Patients With Metastatic Breast, Ovarian, Colon, or… | — | terminated | May 12, 2009 | Mayo Clinic | Due to poor accrual | Enrollment / accrual |
| NCT01126866 | Curative Resectability of Not Optimally Resectable Liver and/or Lung Metastases From…(APRIORI) | Phase 2 | terminated | May 20, 2010 | National Center for Tumor Diseases, Heidelberg | recruiting inadequate | Enrollment / accrual |
| NCT00658801 | Study of Respiratory Gated Proton Beam Radiotherapy for Inoperable Pancreas Carcinoma | Phase 1 | terminated | Apr 15, 2008 | National Cancer Center, Korea | difficult to register | Other (stated, no rule matched) |
| NCT00415454 | Study Combining Suicide Gene Therapy With Chemoradiotherapy in the Treatment of… | Phase 1 | terminated | Dec 25, 2006 | Henry Ford Health System | Poor enrollment | Enrollment / accrual |
| NCT01096745 | Randomized Trial of Gemcitabine/Cisplatin Versus S-1/Cisplatin in Advanced Biliary Cancer | Phase 2 | terminated | Mar 31, 2010 | Gyeongsang National University Hospital | Planning for randomized phase III trial for this issue. | Other (stated, no rule matched) |
| NCT00568308 | Phase III Study of PI-88 in Post-resection Hepatocellular Carcinoma(PATHWAY) | Phase 3 | terminated | Dec 6, 2007 | Progen Pharmaceuticals | Commercial decision to discontinue the study | Other (stated, no rule matched) |
| NCT00550004 | Phase II Study to Evaluate Efficacy and Safety of RP101 in Combination With Gemcitabine(RP101) | Phase 2 | terminated | Oct 26, 2007 | SciClone Pharmaceuticals | not stated | Not stated |
| NCT00326911 | Cetuximab and Bevacizumab With or Without Gemcitabine to Treat Metastatic Pancreatic… | Phase 2 | terminated | May 17, 2006 | Eli Lilly and Company | The planned enrollment was 130 patients and the study was halted prematurely due to lack of… | Efficacy / futility |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Jun 7, 2012source: clinicaltrials