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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,575 stopped studies mapped to Malignant Breast Neoplasm and descendants · 90% state a reason
Over the 1,575 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00351858 | Safety and Efficacy Study of the Trifunctional Antibody Ertumaxomab to Treat Patients…(IV REXBC 02) | Phase 2 | terminated | Jul 13, 2006 | Neovii Biotech | company focus on other projects | Sponsor / business decision |
| NCT01569321 | Diagosis of Breast Carcinoma: Characterization of Breast Lesions With CLEARPEMSONIC :… | N/A | terminated | Apr 3, 2012 | Assistance Publique Hopitaux De Marseille | not stated | Not stated |
| NCT01071564 | RO4929097 and Vismodegib in Treating Patients With Breast Cancer That is Metastatic or… | Phase 1 | terminated | Feb 19, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT02079272 | REBECCA Study (RadiothErapy for BrEast Cancer and CArdiotoxicity)(REBECCA) | N/A | withdrawn | Mar 5, 2014 | Sophie JACOB | not stated | Not stated |
| NCT01368263 | Goserelin and Letrozole or Anastrozole in Premenopausal Patients With Stage II-III… | Phase 2 | terminated | Jun 7, 2011 | Washington University School of Medicine | Due to funding source and lack of accrual | Enrollment / accrual |
| NCT01008514 | Partial-Breast Radiation Therapy in Treating Women With Early-Stage Breast Cancer | Phase 2 | withdrawn | Nov 5, 2009 | Ohio State University Comprehensive Cancer Center | funding issues and Principal Investigator leaving the institution | Investigator |
| NCT00450879 | Pazopanib in Treating Patients With Newly Diagnosed or Locally and/or Regionally… | Phase 1 | terminated | Mar 22, 2007 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01019512 | Flexitouch Lymphedema System in Treating Stage II Lymphedema in Patients With Breast… | N/A | terminated | Nov 24, 2009 | Abramson Cancer Center at Penn Medicine | not stated | Not stated |
| NCT02008994 | Phase II Study Using Genomic & Proteomic Profiling to Influence Treatments for Patients… | Phase 2 | terminated | Dec 11, 2013 | Sanford Health | Resignation of Principal Investigator | Investigator |
| NCT00132002 | Suberoylanilide Hydroxamic Acid in Treating Patients With Progressive Stage IV Breast… | Phase 2 | terminated | Aug 19, 2005 | National Cancer Institute (NCI) | Early termination for discouraging results | Other (stated, no rule matched) |
| NCT00873600 | Outpatient Health Care Program for Older Patients Receiving Chemotherapy for Newly… | — | withdrawn | Apr 1, 2009 | Case Comprehensive Cancer Center | No accrual | Enrollment / accrual |
| NCT00635245 | CP-751871 In Treating Women With Early-Stage Breast Cancer That Can Be Removed By Surgery | Phase 1 | withdrawn | Mar 13, 2008 | Pfizer | not stated | Not stated |
| NCT01239251 | GlowCap Reminder System in Patients With Early Stage Breast Cancer Receiving Adjuvant… | — | terminated | Nov 11, 2010 | Memorial Sloan Kettering Cancer Center | not stated | Not stated |
| NCT00575978 | Hydralazine as Demethylating Agent in Breast Cancer | Phase 1 / Phase 2 | withdrawn | Dec 18, 2007 | University of Arkansas | IRB request | Other (stated, no rule matched) |
| NCT00579319 | Use of Breast MRI for Local Staging | — | withdrawn | Dec 24, 2007 | University of Arkansas | There were no subjects ever enrolled. Study was closed at the IRB. | Enrollment / accrual |
| NCT00579735 | Histologic Diagnoses of Incidentally Detected Lesions on MRI | — | withdrawn | Dec 24, 2007 | University of Arkansas | No subjects were ever enrolled. This study was closed at the IRB. | Enrollment / accrual |
| NCT02024074 | Evaluation of Magnetic Resonance Imaging (MRI) vs Molecular Breast Imaging (Tc-MBI) in… | Phase 1 | terminated | Dec 31, 2013 | Emory University | Study terminated by the Sponsor due to slow enrollment | Enrollment / accrual |
| NCT00539968 | A Study to Evaluate the Safety, Tolerability, and Activity of Lonafarnib and Docetaxel… | Phase 1 / Phase 2 | terminated | Oct 5, 2007 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT01166581 | Impact of Breast Magnetic Resonance Imaging (MRI) on Mastectomy Rates | — | terminated | Jul 21, 2010 | Summa Health System | Not enough data collected to work with | Other (stated, no rule matched) |
| NCT00903006 | Trial of Fulvestrant, MK-0646, and Dasatinib for Metastatic Hormone Receptor-Positive… | Phase 1 / Phase 2 | terminated | May 15, 2009 | M.D. Anderson Cancer Center | Low Accrual | Enrollment / accrual |
| NCT00525161 | Study Adding Multikinase Inhibitor Sorafenib to Existing Endocrine Therapy in Patients… | Phase 2 | terminated | Sep 5, 2007 | Suleiman Massarweh | Slow accrual and loss of funding | Enrollment / accrual |
| NCT01194908 | Re-expression of ER in Triple Negative Breast Cancers | Phase 1 / Phase 2 | terminated | Sep 3, 2010 | Emory University | Slow accrual | Enrollment / accrual |
| NCT00511576 | Study to Evaluate Combination Treatment of MGCD0103 and Docetaxel (Taxotere®) for… | Phase 1 | terminated | Aug 6, 2007 | Mirati Therapeutics Inc. | Celgene terminated its collaboration agreement with MethylGene for the development of MGCD0103. All… | Other (stated, no rule matched) |
| NCT01290718 | A Study of Herceptin (Trastuzumab) in Combination With Xeloda (Capecitabine) in Patients… | Phase 2 | terminated | Feb 7, 2011 | Hoffmann-La Roche | Slow recruitment | Enrollment / accrual |
| NCT00053911 | Combination Chemotherapy Compared With Observation After Surgery in Treating Women With… | Phase 3 | terminated | Feb 6, 2003 | UNICANCER | not stated | Not stated |
| NCT01207102 | Study Of Abraxane® And Carboplatin As First-Line Treatment For Triple Negative Metastatic… | Phase 2 | terminated | Sep 22, 2010 | Duke University | Low enrollment and there is insufficient data to publish. | Enrollment / accrual |
| NCT01479946 | Electrochemotherapy For The Treatment Of Breast Cancer That Has Spread to the Skin | Phase 2 | withdrawn | Nov 28, 2011 | Uppsala University Hospital | ECT equipment not available at study center | Other (stated, no rule matched) |
| NCT01582685 | Exercise in Breast Cancer Survivors | N/A | withdrawn | Apr 23, 2012 | University of Mississippi Medical Center | no patients enrolled | Enrollment / accrual |
| NCT02166983 | Cognitive Enhancement Program in Improving Cognitive Function in Breast Cancer Survivors | N/A | withdrawn | Jun 18, 2014 | Stanford University | PI left Stanford | Investigator |
| NCT01238029 | Dose Finding Study for Combination of Capecitabine, Lapatinib and Vinorelbine in…(CELAVIE) | Phase 1 | terminated | Nov 10, 2010 | Sponsor GmbH | new methods of treatment, no more patients appilicable for study | Other (stated, no rule matched) |
| NCT00756470 | Phase II Neoadjuvant in Inflammatory Breast Cancer | Phase 2 | terminated | Sep 22, 2008 | M.D. Anderson Cancer Center | Slow accrual. | Enrollment / accrual |
| NCT01320787 | 18-F-Fluoroacetate as PET Imaging Agent | Phase 1 | withdrawn | Mar 22, 2011 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT01791998 | Magnetic Resonance Thermal Image Guided Laser Interstitial Thermal Therapy in Treating… | N/A | withdrawn | Feb 15, 2013 | University of Chicago | Funding was time sensitive and expired. No subjects enrolled. | Enrollment / accrual |
| NCT00082095 | To Compare Treatment With Doxorubicin or Capecitabine for Metastatic Breast Cancer in… | Phase 3 | terminated | Apr 30, 2004 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | The study was terminated due to poor recruitment (after enrolling 62 of planned 300 patients in 20… | Enrollment / accrual |
| NCT01939483 | A Pilot Study of Irinotecan in Patients With Breast Cancer and CNS Metastases | N/A | withdrawn | Sep 11, 2013 | University of California, Irvine | Slow accrual | Enrollment / accrual |
| NCT02115594 | Phase 2 Study of Fulvestrant With and Without Entinostat in Postmenopausal Women With ER+…(ENCORE305) | Phase 2 | withdrawn | Apr 16, 2014 | Syndax Pharmaceuticals | Internal decision | Other (stated, no rule matched) |
| NCT01928615 | A Study of Subcutaneously Administered Herceptin (Trastuzumab) in Patients With Human…(LISAH) | Phase 2 | terminated | Aug 27, 2013 | Hoffmann-La Roche | Problems with drug supply | Drug supply |
| NCT01300871 | Alopecia Secondary to Endocrine Therapy in Postmenopausal Women With Breast Cancer | — | terminated | Feb 23, 2011 | University Health Network, Toronto | Poor patient accrual | Enrollment / accrual |
| NCT01272141 | A Study of Lapatinib in Combination With Everolimus in Patients With Advanced, Triple… | Phase 2 | terminated | Jan 7, 2011 | Emory University | Slow accrual, Funding stopped | Enrollment / accrual |
| NCT00570908 | Brain Mets - Capecitabine Plus Sunitinib and WBRT | Phase 2 | terminated | Dec 11, 2007 | Baylor Breast Care Center | Due to poor accrual this study is being closed to accrual | Enrollment / accrual |
| NCT01333137 | A Clinical Trial Comparing Gemcitabine and Carboplatin With and Without P276-00 in… | Phase 1 | terminated | Apr 11, 2011 | Piramal Enterprises Limited | not stated | Not stated |
| NCT00691912 | Therapy of Metastatic Breast Cancer With Paclitaxel and Liposomal Doxorubicin(MyoPac) | Phase 2 | terminated | Jun 6, 2008 | Claudia Lorenz-Schlüter | Study was stopped due because recrutation.was much slower as anticipated. | Other (stated, no rule matched) |
| NCT00524459 | Pegylated Liposomal Doxorubicin and Docetaxel in Treating Women With Locally Advanced… | Phase 2 | terminated | Sep 3, 2007 | Roswell Park Cancer Institute | Terminated by sponsor due to lack of funding | Funding |
| NCT01430585 | Pre-Operative Study of PF-4691502 With Letrozole Compared To Letrozole Alone In Patients… | Phase 2 | terminated | Sep 8, 2011 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT00576901 | A Study of Avastin (Bevacizumab) in Combination With Xeloda (Capecitabine) and Docetaxel… | Phase 2 | terminated | Dec 19, 2007 | Hoffmann-La Roche | The sample for statistical analysis of results could not be recruited within the specified… | Investigator |
| NCT01363986 | A Study of Herceptin (Trastuzumab) in Combination With Whole Brain Radiotherapy in… | Phase 2 | terminated | Jun 2, 2011 | Hoffmann-La Roche | Study was prematurely terminated due to difficulties experienced in recruiting patients in a… | Enrollment / accrual |
| NCT01113905 | Role of Beta-Endorphin in Cancer Therapy Fatigue | — | terminated | Apr 30, 2010 | Massachusetts General Hospital | Insufficient recruitment was obtained | Enrollment / accrual |
| NCT01276054 | Sentinel and/or Axillary Lymph Node Biopsy With or Without Axillary Reverse Mapping in… | Phase 2 | terminated | Jan 13, 2011 | University of Southern California | P.I. left | Other (stated, no rule matched) |
| NCT01151215 | Study of Anastrozole +/- AZD8931 in Postmenopausal Women With Endocrine Therapy Naive…(MINT) | Phase 2 | terminated | Jun 28, 2010 | AstraZeneca | Futility | Efficacy / futility |
| NCT00925548 | STRIDE - STimulating Immune Response In aDvanced brEast Cancer(STRIDE) | Phase 3 | terminated | Jun 22, 2009 | EMD Serono | See termination reason in the below Purpose statement | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated May 1, 2015source: clinicaltrials