Clinical trial · Interventional
Exercise in Breast Cancer Survivors
Exercise in Breast Cancer Survivors: Analysis of Angiogenic Profile
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): no patients enrolled
Summary
Brief summary (as posted)
The investigators hypothesize that exercise in postmenopausal breast cancer survivors will result in an increase in the plasma concentrations of angiostatic factors and a decrease in the plasma concentrations of angiogenic factors. Exercise is expected to result in a circulating angiostatic phenotype that inhibits adipose tissue mass, growth of breast cancer tumor, growth of microscopic residual disease after breast cancer resection, decreases rates of local-regional recurrence, decreases rates of distant recurrence, and increases survival.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Obesity | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Exercise | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Exercise Group
- description
- The intervention is a structured walking program which will be performed partly in the Pavilion Physical Therapy clinic and partly at home. The participant will be instructed in how hard to exercise, how long to exercise, and how many times in a week to exercise. You will also be instructed in how to exercise safely.
- interventionNames
- Behavioral: Exercise
- type
- NO_INTERVENTION
- label
- No Exercise
- description
- These participants will receive standard of care follow up.
Primary outcomes (1)
- measure
- Number of participants that complete the study as a measure of feasibility of an exercise intervention in obese breast cancer survivors.
- timeFrame
- 12 months
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * \> 18 years of age and \< 65 years of age * Female * BMI \> 25 * Weight \< 350 pounds * English as a primary language * Postmenopausal * Invasive ER-positive cancer on biopsy and subsequent definitive surgical therapy * Received and Completed standard of care adjuvant therapy (Concurrent endocrine therapy acceptable) * 6-12 months after completion of therapy (excluding adjuvant endocrine therapy) at time of randomization Exclusion Criteria: * Recurrent breast cancer * DCIS only (no invasive component) * Taking a Beta Blocker or Verapamil * Pregnant * Wheelchair bound * Unable to ambulate independently * Concurrent uncontrolled medical or psychiatric disorder * Open wound * Stage IV breast cancer * Progression of disease * Bilateral mastectomies
References
Publications (0)
Data not yet available