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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
208 stopped studies mapped to Male Reproductive System Carcinoma and descendants · 97% state a reason
Over the 208 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT04399824 | Focal Radiation Therapy for the Treatment of Low or Intermediate-Risk Prostate Cancer | N/A | withdrawn | May 22, 2020 | Jonsson Comprehensive Cancer Center | Study did not open | Other (stated, no rule matched) |
| NCT03570476 | Olaparib Before Surgery in Treating Participants With Localized Prostate Cancer | Phase 2 | terminated | Jun 27, 2018 | University of Washington | Terminated due to slow accrual | Enrollment / accrual |
| NCT01859689 | Internal Radiation Therapy in Treating Patients With Low-Risk Prostate Cancer | Phase 2 | withdrawn | May 22, 2013 | Jonsson Comprehensive Cancer Center | no participants enrolled | Enrollment / accrual |
| NCT02597894 | Targeted Biopsies in Determining Response in Patients With Prostate Cancer Undergoing… | N/A | withdrawn | Nov 5, 2015 | Jonsson Comprehensive Cancer Center | P. I. left the Institution. Study never opened | Other (stated, no rule matched) |
| NCT02168062 | Supportive Therapy in Androgen Deprivation Clinic in Improving Health Outcomes and… | Phase 2 | terminated | Jun 20, 2014 | University of California, San Francisco | Funding | Funding |
| NCT03596710 | Image-Guided Biopsies in Identifying Mechanisms of Resistance in Participants With… | N/A | withdrawn | Jul 24, 2018 | Jonsson Comprehensive Cancer Center | sponsor withdrew study | Other (stated, no rule matched) |
| NCT03827473 | Docetaxel or Abiraterone Acetate With ADT in Treating Patients With Metastatic Hormone…(ACADEMIC) | Phase 2 | terminated | Feb 1, 2019 | University of Utah | The trial was closed because the changing standard of care landscape, making this trial not… | Other (stated, no rule matched) |
| NCT02541903 | Trial Using Gilotrif for Advanced Penile Squamous Cell Carcinoma | Phase 2 | terminated | Sep 4, 2015 | University of Alabama at Birmingham | poor overall accrual | Enrollment / accrual |
| NCT03137758 | A Phase I Study of PCUR-101 in Combination With Androgen Suppression Therapy in the… | Phase 1 | terminated | May 3, 2017 | Pellficure Pharmaceuticals, Inc | Reformulation of study drug to help reduce the pill burden as higher doses are evaluated. | Other (stated, no rule matched) |
| NCT00937768 | Leuprolide Acetate or Goserelin Acetate Compared With Observation in Treating Patients… | Phase 2 | terminated | Jul 13, 2009 | Mayo Clinic | not stated | Not stated |
| NCT01253642 | Phenelzine Sulfate and Docetaxel in Treating Patients With Prostate Cancer With… | Phase 2 | terminated | Dec 3, 2010 | OHSU Knight Cancer Institute | low enrollment | Enrollment / accrual |
| NCT03408561 | Social Media Listening in Improving Clinical Trial Recruitment in Patients With Cancer | N/A | withdrawn | Jan 24, 2018 | University of Southern California | No accrual | Enrollment / accrual |
| NCT03011749 | Value of FLT PET/CT in Radium-223 Therapy of mCRPC Patients | N/A | terminated | Jan 5, 2017 | Rigshospitalet, Denmark | not stated | Not stated |
| NCT01126879 | Genistein in Treating Patients With Prostate Cancer | Phase 2 | terminated | May 20, 2010 | Northwestern University | Closed due to low accrual | Enrollment / accrual |
| NCT01737151 | Stereotactic Body Radiation Therapy in Treating Patients With Low- and Intermediate-Risk… | N/A | terminated | Nov 29, 2012 | Virginia Commonwealth University | Slow accrual | Enrollment / accrual |
| NCT01981109 | Positive Imaging Study for Distant Metastases in Patients With Castration-Resistant…(PREDICT) | — | terminated | Nov 11, 2013 | Dendreon | Administrative reasons | Other (stated, no rule matched) |
| NCT02501759 | Transrectal MRI-Guided Biopsy in Identifying Cancer in Patients With Suspected Prostate… | N/A | terminated | Jul 17, 2015 | OHSU Knight Cancer Institute | Low enrollment and funding loss. | Enrollment / accrual |
| NCT01163084 | Leuprolide Acetate or Goserelin Acetate With or Without Vismodegib Followed by Surgery in… | Phase 1 / Phase 2 | terminated | Jul 15, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT03147196 | Bicalutamide and Raloxifene Hydrochloride in Treating Patients With Prostate Cancer… | Phase 2 | withdrawn | May 10, 2017 | Mayo Clinic | lack of accrual | Enrollment / accrual |
| NCT01703065 | Cabozantinib in Men With Castration-Resistant Prostate Cancer | Phase 2 | terminated | Oct 10, 2012 | University of Washington | Closed 2017 for low accrual. Last data for primary outcome on 02Feb2015. | Enrollment / accrual |
| NCT01795365 | Active Surveillance of 2 Groups of Patients With Localized Prostate Cancer | N/A | terminated | Feb 20, 2013 | Centre Hospitalier Universitaire Vaudois | Participants are no longer being examined and receiving intervention. | Other (stated, no rule matched) |
| NCT01618838 | Endoscopic Evaluation of Late Rectal Injury Following CyberKnife Radiosurgery for… | N/A | terminated | Jun 13, 2012 | Georgetown University | The study only accrued 4 patients in 2 years, far below target (40). It was closed with no subject… | Enrollment / accrual |
| NCT00527124 | Docetaxel and Prednisone With or Without Cediranib in Treating Patients With Metastatic… | Phase 2 | terminated | Sep 10, 2007 | National Cancer Institute (NCI) | Closure was recommended by CTEP due to slow accrual. | Enrollment / accrual |
| NCT02491411 | Dexamethasone Prior to Re-treatment With Enzalutamide in Treating Patients With…(DEXTER) | N/A | terminated | Jul 8, 2015 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | The study is terminated due to lower enrollment | Enrollment / accrual |
| NCT02215161 | Selinexor in Treating Patients With Abiraterone Acetate and/or Enzalutamide Refractory… | Phase 2 | terminated | Aug 13, 2014 | University of California, San Francisco | Risk to benefit ratio is not acceptable | Other (stated, no rule matched) |
| NCT01522443 | Study of Cabozantinib (XL184) Versus Mitoxantrone Plus Prednisone in Men With Previously…(COMET-2) | Phase 3 | terminated | Jan 31, 2012 | Exelixis | Stopped after the outcome of cabozantinib Phase 3 CRPC study XL184-307. | Other (stated, no rule matched) |
| NCT02441517 | A Study of Enzalutamide Re-treatment in Metastatic Castration-resistant Prostate Cancer… | Phase 4 | terminated | May 12, 2015 | Astellas Pharma Global Development, Inc. | The study is closed early due to lck of enrollment. | Enrollment / accrual |
| NCT01200810 | Bicalutamide and RO4929097 in Treating Patients With Previously Treated Prostate Cancer | Phase 2 | terminated | Sep 14, 2010 | National Cancer Institute (NCI) | Drug was no longer available | Other (stated, no rule matched) |
| NCT02564549 | MRI-Based Active Surveillance to Avoid the Risks of Serial Biopsies in Men With Low-Risk… | N/A | terminated | Sep 30, 2015 | Virginia Commonwealth University | Study halted prematurely and will not resume | Other (stated, no rule matched) |
| NCT01145508 | Docetaxel and Prednisone With or Without Vaccine Therapy in Treating Patients With… | Phase 2 | terminated | Jun 16, 2010 | National Cancer Institute (NCI) | Poor accrual | Enrollment / accrual |
| NCT01866423 | Orteronel in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer | Phase 2 | terminated | May 31, 2013 | University of Southern California | Not progressing toward scientific goals | Other (stated, no rule matched) |
| NCT00536991 | Calcitriol in Combination With Ketoconazole and Therapeutic Hydrocortisone in Treating… | Phase 1 / Phase 2 | terminated | Sep 28, 2007 | Roswell Park Cancer Institute | difficult to recruit | Enrollment / accrual |
| NCT02429804 | NaF/FDG PET/MRI in Measuring Response to Radium Ra 223 Dichloride in Patients With… | Phase 1 | terminated | Apr 29, 2015 | Stanford University | Accrual factor | Enrollment / accrual |
| NCT01913015 | Dietary Fat Levels and Abiraterone Acetate Uptake in Patients With Metastatic… | Phase 1 | terminated | Jul 31, 2013 | OHSU Knight Cancer Institute | After enrollment of the first 3 subjects, an interim assessment was conducted. Comparing DBS… | Enrollment / accrual |
| NCT02840162 | Pre-Prostatectomy Celecoxib or Placebo | Phase 2 | terminated | Jul 21, 2016 | OHSU Knight Cancer Institute | Drug safety concerns | Safety / toxicity |
| NCT02370355 | Molecular Characterization of CTCs and ctDNA in Blood and Plasma Samples From Patients… | — | terminated | Feb 24, 2015 | University of Southern California | Sponsor decided not to pursue study | Sponsor / business decision |
| NCT01450683 | Study of Itraconazole in Castrate-resistant Prostate Cancer (CRPC) Post-chemotherapy | Phase 2 | terminated | Oct 12, 2011 | Stanford University | Low accrual | Enrollment / accrual |
| NCT02421575 | Hydroxychloroquine in Blocking Autophagy in Patients With Prostate Cancer Undergoing… | Early Phase 1 | terminated | Apr 20, 2015 | Rutgers, The State University of New Jersey | slow accrual | Enrollment / accrual |
| NCT00879619 | Taxotere/Prednisone Plus Sunitinib in Chemotherapy-Naïve, Hormone Refractory Prostate… | Phase 1 / Phase 2 | terminated | Apr 10, 2009 | John P. Fruehauf | Terminated due to slow accrual. | Enrollment / accrual |
| NCT00598858 | Neoadjuvant Docetaxel on Newly Diagnosed Intermediate and High Grade Cancer of the…(2007-5904) | Phase 2 | withdrawn | Jan 23, 2008 | John P. Fruehauf | Halted due to zero accrual and lack of funding | Enrollment / accrual |
| NCT02279576 | Study With Pazopanib and Weekly Paclitaxel in Penile Carcinoma (PAZOPEN-SOGUG)(PAZOPEN-SOGUG) | Phase 2 | terminated | Oct 31, 2014 | Spanish Oncology Genito-Urinary Group | The low recruitment of patients will not allow to complete the study with the required number of… | Enrollment / accrual |
| NCT02140138 | An Open Label Randomised Trial of RNActive® Cancer Vaccine in High Risk and Intermediate… | Phase 2 | terminated | May 16, 2014 | CureVac | Recruitment was terminated after enrolment of 35 instead of 36 evaluable patients for… | Enrollment / accrual |
| NCT01981707 | F-choline PET in Early Response Assessment for Castration Resistant Prostatic Cancer(PRECHOL) | Phase 2 / Phase 3 | terminated | Nov 11, 2013 | University Hospital, Grenoble | enrollment default | Enrollment / accrual |
| NCT02014831 | Efficacy and Safety of Cetuximab in Metastatic Penile Carcinoma (PENILANE)(PENILANE) | Phase 2 | withdrawn | Dec 18, 2013 | Centre Leon Berard | Industry decline to supply study drug | Drug supply |
| NCT02130947 | Exercise Intervention for Pts With Metastatic Castration-Resistant Prostate Cancer… | N/A | withdrawn | May 6, 2014 | UNC Lineberger Comprehensive Cancer Center | We were not able to accrue any participants. | Enrollment / accrual |
| NCT02396368 | A Study of Radium-223 in Combination With Tasquinimod in Bone-only Metastatic…(Radium-223) | Phase 1 | withdrawn | Mar 24, 2015 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Phase III study results for the drug Tesquinimod were not promising so it was a drug development… | Other (stated, no rule matched) |
| NCT02024685 | Treatment Decision Analysis Model for Prostate Cancer: A Randomized Trial | N/A | terminated | Dec 31, 2013 | Case Comprehensive Cancer Center | Funding unavailable | Funding |
| NCT01368003 | STA-9090 in Castration-Resistant Prostate Cancer With Assessment of Androgen Receptor… | Phase 2 | withdrawn | Jun 7, 2011 | Toni Choueiri, MD | Loss of funding. | Funding |
| NCT01561482 | Study of Metformin With Simvastatin for Men With Prostate Carcinoma | Phase 2 | withdrawn | Mar 23, 2012 | Nicholas Mitsiades | Study closed due to slow/low enrollment; no subjects were enrolled. | Enrollment / accrual |
| NCT00058214 | Perifosine in Treating Patients With Recurrent Prostate Cancer | Phase 2 | terminated | Apr 9, 2003 | National Cancer Institute (NCI) | Did not meet interim stopping criteria for continuation to the second stage. | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Nov 6, 2020source: clinicaltrials