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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,439 stopped studies mapped to Leukemia and descendants · 87% state a reason
Over the 1,439 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00112619 | Topotecan in Treating Young Patients With Neoplastic Meningitis Due to Leukemia,… | Phase 1 | terminated | Jun 3, 2005 | Pediatric Brain Tumor Consortium | Slow accrual and company withdrawing support to supply the drug | Drug supply |
| NCT00162513 | Allogeneic Tumor Cell Vaccination in Patients With Chronic Myeloid Leukemia | Phase 1 / Phase 2 | withdrawn | Sep 13, 2005 | Hadassah Medical Organization | PI is no longer work at Hadassah | Other (stated, no rule matched) |
| NCT00531310 | Reduced Intensity AlloSCT in(CML) With Persistent Disease(CML) | Phase 2 | terminated | Sep 18, 2007 | Columbia University | Poor accrual | Enrollment / accrual |
| NCT00226512 | To Determine the Role of Adding Campath-1H or ATG Given In-vivo in Addition to… | Phase 3 | withdrawn | Sep 27, 2005 | Hadassah Medical Organization | the PI is no longer work at Hadassah | Other (stated, no rule matched) |
| NCT00187005 | Total Therapy Study XIV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia | Phase 3 | terminated | Sep 16, 2005 | St. Jude Children's Research Hospital | Toxicity | Safety / toxicity |
| NCT00813501 | Immunologic Diagnostic Blood Test in Predicting Side-Effects in Patients Undergoing a… | — | terminated | Dec 23, 2008 | City of Hope Medical Center | Terminated at the request of the study sponsor | Other (stated, no rule matched) |
| NCT01034410 | A Study of AS1411 Combined With Cytarabine in the Treatment of Patients With Primary… | Phase 2 | terminated | Dec 17, 2009 | Antisoma Research | not stated | Not stated |
| NCT00486265 | Phase I/II, Open-label, Multi-center, Two Part Dose-escalation, Safety, Pharmacokinetics… | Phase 1 | terminated | Jun 14, 2007 | AstraZeneca | AML assess. of response in Part B patients find treatment failure in all 8 evaluable for marrow… | Other (stated, no rule matched) |
| NCT00631059 | Assessment and Determination of Chemotherapy Resistance in Newly-Diagnosed or First… | N/A | terminated | Mar 7, 2008 | University of California, Irvine | Haluted due to slow accrual | Enrollment / accrual |
| NCT00279773 | Safety, Pharmacokinetics and Pharmacodynamics of TKI258 in Subjects With Acute Myeloid… | Phase 1 | terminated | Jan 20, 2006 | Novartis Pharmaceuticals | Study was stopped due to time dependent drug accumulation | Other (stated, no rule matched) |
| NCT00646165 | Trial of Forodesine in Patients With Relapsed B-cell Chronic Lymphocytic Leukemia | Phase 1 | terminated | Mar 28, 2008 | Mundipharma Research Limited | Poor recruitment and change in development strategy | Enrollment / accrual |
| NCT00319930 | Phase 1, Dose-Escalation, Pharmacodynamic Study of IV CNF1010 in ZAP-70 Positive CLL | Phase 1 | terminated | Apr 27, 2006 | Biogen | Discontinuation of program | Other (stated, no rule matched) |
| NCT00918450 | Study Assessing the Safety and Efficacy of ABT-263 in Subjects With B-cell Chronic… | Phase 2 | withdrawn | Jun 11, 2009 | Abbott | Sponsor has decided to not proceed with this study. | Other (stated, no rule matched) |
| NCT00322673 | Study of XL999 in Patients With Acute Myeloid Leukemia (AML) | Phase 2 | terminated | May 8, 2006 | Symphony Evolution, Inc. | Study was terminated due to cardiac toxicities | Safety / toxicity |
| NCT00004058 | 12-O-Tetradecanoylphorbol-13-acetate in Treating Patients With Hematologic Cancer or Bone… | Phase 1 | terminated | Jan 27, 2003 | University of Medicine and Dentistry of New Jersey | At this time it is felt that we will not gain further information from an additional patients. | Other (stated, no rule matched) |
| NCT00362466 | A Study of Dasatinib vs. High-Dose Imatinib (600 mg) in Patients With Chronic Phase… | Phase 3 | terminated | Aug 10, 2006 | Bristol-Myers Squibb | Insufficient Enrollment | Enrollment / accrual |
| NCT00306332 | T-cell and B-cell Depletion in Allogeneic Peripheral Blood Stem Cell Transplantation | Phase 3 | terminated | Mar 23, 2006 | Radboud University Medical Center | Interim analysis has shown that the objectives of this study can not be reached | Efficacy / futility |
| NCT00344786 | Phase 1, Dose-Escalation Study of Oral CNF2024(BIIB021) in CLL | Phase 1 | terminated | Jun 27, 2006 | Biogen | Sponsor's decision | Sponsor / business decision |
| NCT00543972 | Dose Escalation Safety and Pharmacokinetic Study of AVE9633 as Single Agent in… | Phase 1 | terminated | Oct 15, 2007 | Sanofi | due to absence of evidence of clinical activity up to toxic doses | Other (stated, no rule matched) |
| NCT00461929 | Chromosome Abnormalities in Chronic Myeloid Leukemia (CML) on Imatinib. GIST Patients on…(GIST) | Phase 4 | terminated | Apr 18, 2007 | University Health Network, Toronto | study terminated 12Feb09 due to low recruitment | Enrollment / accrual |
| NCT00485966 | Study Evaluating Effects of CX-3543 in Patients With Relapsed or Refractory B-Cell… | Phase 2 | withdrawn | Jun 13, 2007 | Cylene Pharmaceuticals | This study was withdrawn prior to patient enrollment | Enrollment / accrual |
| NCT00594555 | A Study Evaluating the Effects of CLAG With Gleevec in Refractory or Relapsed Acute… | Phase 2 | withdrawn | Jan 15, 2008 | University of Cincinnati | Principal Investigator resigned position with the University of Cincinnati, closing study at this… | Investigator |
| NCT00676871 | A Study to Evaluate the Safety, Tolerability, and Antitumor Activity of Continuous… | Phase 1 / Phase 2 | withdrawn | May 13, 2008 | MedImmune LLC | Replacing this trial with a new trial. | Other (stated, no rule matched) |
| NCT00234481 | Safety Study of XL844 in Subjects With Chronic Lymphocytic Leukemia | Phase 1 | terminated | Oct 7, 2005 | Exelixis | Study closed due to slow enrollment | Enrollment / accrual |
| NCT00302861 | A Study to Evaluate the Treatment of Previously Untreated B-Cell Chronic Lymphocytic… | Phase 1 / Phase 2 | terminated | Mar 15, 2006 | Genitope Corporation | not stated | Not stated |
| NCT00363025 | A Randomized Study of Post-Remission Therapy in Elderly Patients With Acute Myelogenous… | Phase 3 | terminated | Aug 15, 2006 | Acute Leukemia French Association | not stated | Not stated |
| NCT00517218 | This Study is Being Performed to Evaluate the Effect of Genasense on the Efficacy and the… | Phase 3 | withdrawn | Aug 16, 2007 | Genta Incorporated | not stated | Not stated |
| NCT00104468 | Study of Troxatyl™ Administered by Continuous Infusion to Subjects With Refractory Acute… | Phase 1 / Phase 2 | terminated | Mar 1, 2005 | SGX Pharmaceuticals, Inc. | Trial stopped June 2007 | Other (stated, no rule matched) |
| NCT00077493 | BL22 Immunotoxin In Treating Young Patients With Relapsed or Refractory Acute… | Phase 1 | suspended | Feb 12, 2004 | MedImmune LLC | protocol development and Amended protocol revision | Other (stated, no rule matched) |
| NCT00165087 | Treatment of Childhood Acute Lymphoblastic Leukemia | Phase 3 | terminated | Sep 14, 2005 | Dana-Farber Cancer Institute | Terminated by IRB for continuing review | Other (stated, no rule matched) |
| NCT00511121 | Study of the Combination of a Tyrosine Kinase Inhibitor (STI571) and a Pegylated Human… | Phase 2 | terminated | Aug 3, 2007 | University of Bologna | not stated | Not stated |
| NCT00105313 | Study to Evaluate MEDI-507 in Patients With CD2-Positive Lymphoma/Leukemia | Phase 1 | terminated | Mar 14, 2005 | MedImmune LLC | After review of safety events and have decided that further dose escalation of MEDI-507 as a single… | Safety / toxicity |
| NCT00126893 | Study to Determine the Optimal Biologic Dose of CC-401 in Subjects With High-Risk Myeloid… | Phase 1 | terminated | Aug 5, 2005 | Celgene Corporation | not stated | Not stated |
| NCT00143884 | Study of Low Intensity Conditioning and Immunotherapy for High-Risk Cancers of the Blood | Phase 2 | terminated | Sep 2, 2005 | University of Michigan Rogel Cancer Center | not stated | Not stated |
| NCT00152594 | Voriconazole or Placebo in the Prophylaxis of Lung Infiltrates in Patients Undergoing… | Phase 3 | terminated | Sep 9, 2005 | University of Cologne | not stated | Not stated |
| NCT00129948 | Study for Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) | Phase 2 | terminated | Aug 12, 2005 | SGX Pharmaceuticals, Inc. | not stated | Not stated |
| NCT00329498 | L-Ascorbic Acid Depletion to Treat Acute Myeloid Leukemia and Myelodysplastic Syndromes | Phase 2 | suspended | May 24, 2006 | Samsung Medical Center | not stated | Not stated |
| NCT00219765 | Safety and Efficacy of Imatinib in Combination With High Dose Chemotherapy for Acute… | Phase 1 / Phase 2 | terminated | Sep 22, 2005 | Poitiers University Hospital | not stated | Not stated |
| NCT00083473 | A Pilot Study of Pivanex in Patients With Chronic Lymphocytic Leukemia | Phase 2 | terminated | May 26, 2004 | Titan Pharmaceuticals | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 22 days agoSource updated Jun 30, 2011source: clinicaltrials