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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
830 stopped studies mapped to Genitourinary System Carcinoma and descendants · 90% state a reason
Over the 830 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01934179 | Telomere Length in Predicting Toxicity in Older Patients With Stage III-IV Colorectal… | — | terminated | Sep 4, 2013 | Fox Chase Cancer Center | Low Accrual Rate | Enrollment / accrual |
| NCT02338570 | Outcome-related Factors in Patients With Metastatic Renal Cell Carcinoma Treated With…(ORCHIDEE) | Phase 4 | terminated | Jan 14, 2015 | Mario Negri Institute for Pharmacological Research | Stopped on November 16th 2016, because of recruitment failure. | Enrollment / accrual |
| NCT02514408 | Circulating Tumor Cells in Operative Blood in Patients With Bladder Cancer | — | withdrawn | Aug 3, 2015 | University of Southern California | No funding | Funding |
| NCT03238664 | Robot-Assisted Laparoscopic High-Intensity Focused Ultrasound and Radical Cystectomy for… | N/A | withdrawn | Aug 3, 2017 | University of Southern California | No funding | Funding |
| NCT01762592 | REDECT 2: REnal Masses: Pivotal Trial to DEteCT Clear Cell Renal Cell Carcinoma With… | Phase 3 | withdrawn | Jan 7, 2013 | Heidelberg Pharma AG | new sponsor | Other (stated, no rule matched) |
| NCT02370342 | Robot-Assisted Ultrasound for Thermal Ablative Therapy in Treating Patients With Small… | N/A | withdrawn | Feb 24, 2015 | University of Southern California | No funding | Funding |
| NCT01200810 | Bicalutamide and RO4929097 in Treating Patients With Previously Treated Prostate Cancer | Phase 2 | terminated | Sep 14, 2010 | National Cancer Institute (NCI) | Drug was no longer available | Other (stated, no rule matched) |
| NCT02122003 | Second Line Sorafenib After Pazopanib in Patients With RCC(SOAP) | Phase 2 | terminated | Apr 24, 2014 | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | availability of new and more promising therapeutic agents than expected in the experimentation in… | Other (stated, no rule matched) |
| NCT02944357 | Gemcitabine Hydrochloride, Cisplatin, and AGS-003-BLD in Treating Patients With… | N/A | withdrawn | Oct 25, 2016 | Mayo Clinic | not stated | Not stated |
| NCT00158886 | Oral Topotecan As A Radiosensitizing Agent In Rectal Cancer | Phase 1 | terminated | Sep 12, 2005 | GlaxoSmithKline | not stated | Not stated |
| NCT02138578 | Trial Comparing Stereotactic Body Radiation Therapy to Radiofrequency Ablation for Renal… | N/A | terminated | May 14, 2014 | University of Michigan Rogel Cancer Center | Due to changes in scanning procedure, and infeasible biopsy and baseline imaging, the trial closed… | Enrollment / accrual |
| NCT00070317 | Lymph Node Mapping and Sentinel Lymph Node Identification in Patients With Stage IB1… | N/A | terminated | Oct 7, 2003 | Gynecologic Oncology Group | not stated | Not stated |
| NCT01492192 | RGD-PET-CT in Cancer Angiogenesis | Phase 2 | terminated | Dec 14, 2011 | Oxford University Hospitals NHS Trust | not stated | Not stated |
| NCT02564549 | MRI-Based Active Surveillance to Avoid the Risks of Serial Biopsies in Men With Low-Risk… | N/A | terminated | Sep 30, 2015 | Virginia Commonwealth University | Study halted prematurely and will not resume | Other (stated, no rule matched) |
| NCT01784978 | Efficacy Study of Sunitinib and Everolimus (Rotational vs Sequential Arm) in Pats. With m…(SUNRISES) | Phase 2 | terminated | Feb 6, 2013 | Associació per a la Recerca Oncologica, Spain | Lack of recruitment | Enrollment / accrual |
| NCT01145508 | Docetaxel and Prednisone With or Without Vaccine Therapy in Treating Patients With… | Phase 2 | terminated | Jun 16, 2010 | National Cancer Institute (NCI) | Poor accrual | Enrollment / accrual |
| NCT01866423 | Orteronel in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer | Phase 2 | terminated | May 31, 2013 | University of Southern California | Not progressing toward scientific goals | Other (stated, no rule matched) |
| NCT02089802 | Optimizing Pazopanib Exposure in RCC Patients(OPERA) | Phase 2 | terminated | Mar 18, 2014 | Interessenverband zur Qualitätssicherung der Arbeit niedergelassener Uro-Onkologen in Deutschland e. | Early termination due to lack of recruitment | Enrollment / accrual |
| NCT00004221 | Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients… | Phase 2 | terminated | Aug 25, 2003 | Gynecologic Oncology Group | not stated | Not stated |
| NCT02223975 | Evaluation of the Role of Vibrational Spectroscopy in the Assessment of Vulval Disease(Vulval VS) | — | suspended | Aug 22, 2014 | Gloucestershire Hospitals NHS Foundation Trust | Study suspended pending further funding | Funding |
| NCT01598038 | Relation Between Safety Endpoints and Everolimus Trough Blood Level in Advanced Renal… | N/A | terminated | May 15, 2012 | Centre Francois Baclesse | not stated | Not stated |
| NCT02928263 | Healthcare Cost and Resource Utilization Related to Metastatic Renal Cell Carcinoma… | — | withdrawn | Oct 10, 2016 | Bristol-Myers Squibb | Business objectives have changed | Sponsor / business decision |
| NCT00551265 | Oregovomab With or Without Cyclophosphamide in Treating Patients With Stage III or Stage… | N/A | withdrawn | Oct 30, 2007 | Gynecologic Oncology Group | not stated | Not stated |
| NCT01754519 | Radiation Therapy in Treating Post-Menopausal Women With Early Stage Breast Cancer… | Phase 2 | terminated | Dec 21, 2012 | Roswell Park Cancer Institute | IDE not submitted | Other (stated, no rule matched) |
| NCT01176500 | A Pilot, Open-label Study of 18F-Fluciclatide PET/CT Imaging in the Evaluation of… | Phase 1 / Phase 2 | withdrawn | Aug 6, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01042795 | Trial of Adjuvant Sutent for Patients With High Risk Urothelial Carcinoma After… | Phase 2 | terminated | Jan 6, 2010 | University of Michigan | Study closed due to poor accrual | Enrollment / accrual |
| NCT00536991 | Calcitriol in Combination With Ketoconazole and Therapeutic Hydrocortisone in Treating… | Phase 1 / Phase 2 | terminated | Sep 28, 2007 | Roswell Park Cancer Institute | difficult to recruit | Enrollment / accrual |
| NCT00934440 | A Study to Evaluate the Effectiveness of 5-Azacitidine and Bevacizumab in Advanced Renal…(5-AZ) | Phase 1 / Phase 2 | terminated | Jul 8, 2009 | University of Kansas Medical Center | not stated | Not stated |
| NCT01184053 | Trisenox® in Women With Metastatic Endometrial Cancer(NRR) | Phase 2 | terminated | Aug 18, 2010 | UNC Lineberger Comprehensive Cancer Center | Accrual was very low. No subject had been enrolled in a year. | Enrollment / accrual |
| NCT01599832 | Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Measuring Effects of Pazopanib… | N/A | terminated | May 16, 2012 | University of Chicago | Poor accrual | Enrollment / accrual |
| NCT01681368 | Birinapant for Advanced Ovarian, Fallopian Tube, and Peritoneal Cancer | Phase 2 | terminated | Sep 7, 2012 | National Cancer Institute (NCI) | Accrual was terminated for lack of a clinical benefit. | Enrollment / accrual |
| NCT02429804 | NaF/FDG PET/MRI in Measuring Response to Radium Ra 223 Dichloride in Patients With… | Phase 1 | terminated | Apr 29, 2015 | Stanford University | Accrual factor | Enrollment / accrual |
| NCT01353222 | DN24-02 as Adjuvant Therapy in Subjects With High Risk HER2+ Urothelial Carcinoma | Phase 2 | terminated | May 13, 2011 | Dendreon | Administrative reasons. | Other (stated, no rule matched) |
| NCT02742428 | Preoperative Ascites Drainage Versus Standard Care for Patients With Advanced Ovarian… | N/A | suspended | Apr 19, 2016 | Gdynia Oncology Center | The protocol will be discussed and consulted. Potentially will resume. | Other (stated, no rule matched) |
| NCT01494012 | Phase I Stereotactic Body Radiation for Metastatic or Recurrent Platinum-Resistant… | Phase 1 | terminated | Dec 16, 2011 | Stanford University | low accrual | Enrollment / accrual |
| NCT01913015 | Dietary Fat Levels and Abiraterone Acetate Uptake in Patients With Metastatic… | Phase 1 | terminated | Jul 31, 2013 | OHSU Knight Cancer Institute | After enrollment of the first 3 subjects, an interim assessment was conducted. Comparing DBS… | Enrollment / accrual |
| NCT02840162 | Pre-Prostatectomy Celecoxib or Placebo | Phase 2 | terminated | Jul 21, 2016 | OHSU Knight Cancer Institute | Drug safety concerns | Safety / toxicity |
| NCT01138137 | N-acetylcysteine Given IV With Cisplatin and Paclitaxel in Patients With Ovarian Cancer | Phase 1 | withdrawn | Jun 7, 2010 | OHSU Knight Cancer Institute | No funding was available for the cost of the IV N-acetylcysteine (NAC). | Funding |
| NCT02370355 | Molecular Characterization of CTCs and ctDNA in Blood and Plasma Samples From Patients… | — | terminated | Feb 24, 2015 | University of Southern California | Sponsor decided not to pursue study | Sponsor / business decision |
| NCT00651482 | Treatment of Refractory Metastatic Renal Cell Carcinoma With Bevacizumab and RAD001… | Phase 2 | terminated | Apr 2, 2008 | Sandy Srinivas | slow accrual | Enrollment / accrual |
| NCT01450683 | Study of Itraconazole in Castrate-resistant Prostate Cancer (CRPC) Post-chemotherapy | Phase 2 | terminated | Oct 12, 2011 | Stanford University | Low accrual | Enrollment / accrual |
| NCT02071641 | Phase II Study of Sunitinib Rechallenge in Patients With Metastatic Renal Cell Carcinoma | Phase 2 | terminated | Feb 26, 2014 | Amsterdam UMC, location VUmc | not stated | Not stated |
| NCT00698685 | Pentostatin and Alemtuzumab as a Preparative Regimen for Allogeneic Peripheral Blood Stem… | Phase 2 | terminated | Jun 17, 2008 | University of Arizona | Pentostatin/alemtuzumab regimen had greater risk of graft failure. | Other (stated, no rule matched) |
| NCT02218502 | Study Into a New Diagnostic Tool (Simple Ultrasound-based Rules) in Patients With Adnexal…(SUBSONiC) | N/A | terminated | Aug 18, 2014 | Maastricht University Medical Center | interim analysis showed incorrect use of simple rules | Efficacy / futility |
| NCT01943188 | Stereotactic Body Radiation Therapy and T-Cell Infusion in Treating Patients With… | Phase 1 | terminated | Sep 16, 2013 | Stanford University | not stated | Not stated |
| NCT01441765 | PD-1 Alone or With Dendritic Cell/Renal Cell Carcinoma Fusion Cell Vaccine | Phase 2 | terminated | Sep 28, 2011 | Beth Israel Deaconess Medical Center | Funding | Funding |
| NCT02273752 | Pharmacokinetically Guided Everolimus in Patients With Breast Cancer, Pancreatic… | Phase 2 | terminated | Oct 24, 2014 | Emory University | Slow accrual | Enrollment / accrual |
| NCT02421575 | Hydroxychloroquine in Blocking Autophagy in Patients With Prostate Cancer Undergoing… | Early Phase 1 | terminated | Apr 20, 2015 | Rutgers, The State University of New Jersey | slow accrual | Enrollment / accrual |
| NCT00879619 | Taxotere/Prednisone Plus Sunitinib in Chemotherapy-Naïve, Hormone Refractory Prostate… | Phase 1 / Phase 2 | terminated | Apr 10, 2009 | John P. Fruehauf | Terminated due to slow accrual. | Enrollment / accrual |
| NCT00672178 | Stereotactic Body Radiotherapy (SBRT) and Sorafenib in Patients With Metastatic,… | Phase 1 / Phase 2 | terminated | May 6, 2008 | Duke University | Slow accrual | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Feb 7, 2018source: clinicaltrials