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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
3,703 stopped studies mapped to Carcinoma and descendants · 91% state a reason
Over the 3,703 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00732745 | Vandetanib, Oxaliplatin, and Docetaxel in Advanced Cancer of the Esophagus or… | Phase 1 | terminated | Aug 12, 2008 | Case Comprehensive Cancer Center | Lost funding for Phase II portion of study | Funding |
| NCT00805012 | Docetaxel and S-1 in Head and Neck Squamous Cell Carcinoma (HNSCC) | Phase 2 | terminated | Dec 9, 2008 | Seoul National University Hospital | slow accrual rate | Enrollment / accrual |
| NCT00830245 | A Study to Assess the Efficacy of Erlotinib for Leptomeningeal Carcinomatosis in EGFR… | Phase 2 | terminated | Jan 27, 2009 | Clinical Research Center for Solid Tumor, Korea | low accrual rate | Enrollment / accrual |
| NCT00725400 | Comparative Study of Cetuximab and Radiation Vs Surgery Before or After Radiation in… | Phase 2 | withdrawn | Jul 30, 2008 | American Scitech International | Study is withdrawn due to unavailability of eligible subject population. We will request the… | Enrollment / accrual |
| NCT00970645 | Study Comparing EBUS & EUS to Mediastinoscopy in Staging and Detection of Lung Cancer | N/A | terminated | Sep 2, 2009 | Mayo Clinic | Similar study published results | Other (stated, no rule matched) |
| NCT01126866 | Curative Resectability of Not Optimally Resectable Liver and/or Lung Metastases From…(APRIORI) | Phase 2 | terminated | May 20, 2010 | National Center for Tumor Diseases, Heidelberg | recruiting inadequate | Enrollment / accrual |
| NCT00369447 | A Study of Nimotuzumab in Combination With External Radiotherapy in Non-Small Cell Lung… | Phase 1 / Phase 2 | terminated | Aug 29, 2006 | YM BioSciences | The study was closed due to slow accrual. | Enrollment / accrual |
| NCT00872482 | A Study of Nimotuzumab in Combination With Radiation Therapy in Patients With Brain… | Phase 2 | terminated | Mar 31, 2009 | YM BioSciences | Study closed due to low enrollment | Enrollment / accrual |
| NCT00563862 | Benefit of Adding Chemotherapy And/Or Modification of Radiotherapy Schedule for Advance… | N/A | terminated | Nov 26, 2007 | Hospital Authority, Hong Kong | not stated | Not stated |
| NCT00568308 | Phase III Study of PI-88 in Post-resection Hepatocellular Carcinoma(PATHWAY) | Phase 3 | terminated | Dec 6, 2007 | Progen Pharmaceuticals | Commercial decision to discontinue the study | Other (stated, no rule matched) |
| NCT00539331 | Phase I/II Study of AZD2171 in Combination With Paclitaxel/Carboplatin in Japanese… | Phase 1 | terminated | Oct 4, 2007 | AstraZeneca | not stated | Not stated |
| NCT01363466 | Evaluation of Hysterectomy After Chemoradiation Therapy for Stage IB2/II Cervical Cancer | Phase 3 | terminated | Jun 1, 2011 | UNICANCER | low recruitment | Enrollment / accrual |
| NCT00343187 | A Phase II Study of ACZONE™ (Dapsone) Gel, 5% As a Treatment For Tarceva®… | Phase 2 | terminated | Jun 22, 2006 | Allergan | Lack of enrollment | Enrollment / accrual |
| NCT01077869 | A Feasibility Study on the Use of F-18-FDG-PET and Optical Imaging in Evaluation of… | — | terminated | Mar 1, 2010 | University Hospital, Ghent | poor recruitment rate | Enrollment / accrual |
| NCT00234468 | Iressa vs Placebo as Maintenance Therapy in Locally Advanced NSCLC | Phase 3 | terminated | Oct 7, 2005 | AstraZeneca | Closed due to insufficient recruitment | Enrollment / accrual |
| NCT00232206 | Trial of Neoadjuvant Docetaxel and Cisplatin for Resectable Non-Small Cell Lung Cancer | Phase 2 | terminated | Oct 4, 2005 | Providence Health & Services | study terminated due to slow accrual | Enrollment / accrual |
| NCT00470340 | Chemotherapy or Not, Following Complete Treatment of Hepatic Cancer in Cirrhotic Patients(GEMOXIAL) | Phase 3 | terminated | May 7, 2007 | Assistance Publique - Hôpitaux de Paris | during the study | Other (stated, no rule matched) |
| NCT00216216 | Pemetrexed in Patients With Chemosensitive and Chemoresistant Relapsed Small Cell Lung… | Phase 2 | terminated | Sep 22, 2005 | Hoosier Cancer Research Network | The results from the interim analysis were not favorable to continue this trial. | Efficacy / futility |
| NCT01330823 | L-CARnitine in the Palliative Treatment of Advanced PANcreatic Cancer (CARPAN)(CARPAN) | Phase 3 | suspended | Apr 7, 2011 | University Medicine Greifswald | after interims analysis standard errors for inflammatory and nutritional markers varied widely,… | Other (stated, no rule matched) |
| NCT00049959 | Two Studies to Determine if Verteporfin PDT is Effective & Safe in Treating Multiple… | Phase 3 | terminated | Nov 19, 2002 | QLT Inc. | not stated | Not stated |
| NCT00540280 | Randomized Phase III Trial of Surgery Alone or Surgery Plus Preoperative… | Phase 3 | suspended | Oct 5, 2007 | King Faisal Specialist Hospital & Research Center | Follow up only | Other (stated, no rule matched) |
| NCT00863096 | Human Papillomavirus Screening and Vaccine Readiness Program | — | withdrawn | Mar 17, 2009 | Public Health Research Institute, India | Unable to get the vaccine on time to offer it to the study population. | Other (stated, no rule matched) |
| NCT00117351 | VELCADE in Previously Treated Patients With Stage IIIB and IV Bronchioloalveolar… | Phase 2 | terminated | Jul 6, 2005 | Millennium Pharmaceuticals, Inc. | insufficient efficacy | Efficacy / futility |
| NCT00283634 | A Study of Tarceva for Use in Patients With Relapsed or Refractory Metastatic Non-Small… | Phase 2 | terminated | Jan 30, 2006 | Millennium Pharmaceuticals, Inc. | insufficient efficacy | Efficacy / futility |
| NCT00233636 | Iressa and Radiotherapy in the Treatment of the Locally Advanced Inoperable Squamous Cell… | Phase 2 | withdrawn | Oct 6, 2005 | AstraZeneca | not stated | Not stated |
| NCT00065572 | Exploratory Study to Assess the Biological Activity of ZD6126 in Subjects With Newly… | Phase 2 | suspended | Jul 31, 2003 | AstraZeneca | not stated | Not stated |
| NCT00354562 | A Phase 2 Study Evaluating ABT-751 in Combination With Taxotere in Advanced Non-Small… | Phase 1 / Phase 2 | terminated | Jul 20, 2006 | Abbott | not stated | Not stated |
| NCT00721981 | An Evaluation of the Clinical Treatment and Patient Values and Preferences of Patients… | — | terminated | Jul 25, 2008 | AstraZeneca | Low Recruitment | Enrollment / accrual |
| NCT00428597 | A Study Of Sunitinib Compared To Placebo For Patients With Advanced Pancreatic Islet Cell… | Phase 3 | terminated | Jan 30, 2007 | Pfizer | Refer to Detailed Description. | Other (stated, no rule matched) |
| NCT00329472 | Efficacy Study of Induction Chemotherapy Before Surgery in Operable Non-small Cell Lung… | Phase 3 | withdrawn | May 24, 2006 | Samsung Medical Center | poor enrollment | Enrollment / accrual |
| NCT00791544 | Dose Finding Study of AVE1642 in Patients With Advanced or Metastatic Liver Carcinoma | Phase 1 / Phase 2 | terminated | Nov 14, 2008 | Sanofi | Company decision to discontinue the AVE1642 development program, not due to any safety or efficacy… | Safety / toxicity |
| NCT00647140 | Clinical Evaluation of 18F-DOPA Positron Emission Tomography in Medullary Thyroid Cancer(DOPMET) | Phase 2 | terminated | Mar 31, 2008 | Assistance Publique - Hôpitaux de Paris | Insuffisent recruitment | Enrollment / accrual |
| NCT00783471 | Docetaxel Intermittent-Erlotinib (Tarceva®) In Metastatic Non Small Cell Lung Cancer…(DOPERLO) | Phase 2 | terminated | Oct 31, 2008 | Hellenic Cooperative Oncology Group | The low accrual rate of the study (30% of the expected accrual rate)/Low efficacy in both treatment… | Efficacy / futility |
| NCT00515970 | Curettage Versus Excision in Nodular and Superficial Basal Cell Carcinomas | N/A | suspended | Aug 14, 2007 | University Hospital Tuebingen | Problems with the electronic data collection program | Other (stated, no rule matched) |
| NCT00472706 | Trial of Excision Versus Photodynamic Therapy in the Treatment of Bowen's Disease | Phase 4 | terminated | May 14, 2007 | Catharina Ziekenhuis Eindhoven | Study stopped because of disappointing inclusion rates | Other (stated, no rule matched) |
| NCT00280007 | Transarterial Chemoembolisation Plus Bevacizumab for Treatment of Hepatocellular Carcinoma | Phase 2 | terminated | Jan 20, 2006 | Medical University of Vienna | Safety concerns in the treatment arm | Safety / toxicity |
| NCT00201344 | A Phase III Study of Radiotherapy With or Without Adjuvant C/T in Advanced Stage… | Phase 3 | terminated | Sep 20, 2005 | National Health Research Institutes, Taiwan | not stated | Not stated |
| NCT00099879 | Study of BMS-275183 in Patients With Pre-treated Non-small Cell Lung Cancer | Phase 2 | terminated | Dec 22, 2004 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00359450 | Study of BMS-275183 in Patients With Pretreated Locally Advanced or Metastatic NSCLC (Non… | Phase 2 | terminated | Aug 2, 2006 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00909558 | Safety and Effectiveness Study of Autologous Natural Killer and Natural Killer T Cells on… | Phase 1 | suspended | May 28, 2009 | Envita Medical Center, Inc. | not stated | Not stated |
| NCT00277329 | Study of XL999 in Patients With Non-small Cell Lung Cancer | Phase 2 | terminated | Jan 16, 2006 | Symphony Evolution, Inc. | Study was terminated due to cardiac toxicities in the subejcts | Safety / toxicity |
| NCT00277316 | Study of XL999 in Patients With Metastatic Renal Cell Carcinoma | Phase 2 | terminated | Jan 16, 2006 | Symphony Evolution, Inc. | Development of XL999 was stopped due to cardiac toxicities in the subjects | Safety / toxicity |
| NCT00491699 | Safety Study of XL999 in Adults With Non-Small-Cell Lung Cancer | Phase 1 | terminated | Jun 26, 2007 | Symphony Evolution, Inc. | The study was stopped due to safety concerns | Safety / toxicity |
| NCT00540735 | Efficiency Evaluation of Photodynamic Therapy With Photofrin® on Unresectable Type III or…(CK/PDT) | Phase 3 | terminated | Oct 8, 2007 | University Hospital, Angers | Big difficulties to enroll patients | Enrollment / accrual |
| NCT01000896 | Study to Assess Safety and Tolerability of AZD0530 in Combination With Carboplatin and… | Phase 1 | withdrawn | Oct 23, 2009 | AstraZeneca | AstraZeneca has discontinued the development of AZD0530. No new AstraZeneca-sponsored clinical… | Other (stated, no rule matched) |
| NCT00473486 | Study in Patients With Advanced Non-Small Cell Lung Cancer Treated With Pemetrexed and…(PECASO) | Phase 1 / Phase 2 | terminated | May 15, 2007 | University Hospital Muenster | Sorafenib administered in the combination with pemetrexed-carboplatin appears to enhance… | Other (stated, no rule matched) |
| NCT00378573 | Multicenter Evaluation of Docetaxel, Gemcitabine, and Bevacizumab Combination Followed by… | Phase 2 | terminated | Sep 20, 2006 | Sanofi | Incidence of GI Perforation | Other (stated, no rule matched) |
| NCT00264134 | Docetaxel, Irinotecan, and Carboplatin in Extensive Stage Non-Small Cell Lung Cancer | Phase 1 / Phase 2 | terminated | Dec 12, 2005 | Kentuckiana Cancer Institute | not stated | Not stated |
| NCT00271323 | Safety Study of Docetaxel/Cisplatin Induction Therapy Followed by Concurrent… | Phase 2 | terminated | Dec 30, 2005 | Sanofi | not stated | Not stated |
| NCT00557596 | A Phase 1-2, XIAP Antisense AEG35156 With Gemcitabine in Patients With Advanced… | Phase 1 / Phase 2 | terminated | Nov 14, 2007 | Aegera Therapeutics | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Aug 22, 2011source: clinicaltrials