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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,440 stopped studies mapped to Adenocarcinoma and descendants · 92% state a reason
Over the 1,440 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT03358004 | the Role of Two Different Metronomic Chemotherapy Regimens in Locally Advanced or…(VICTOR3) | Phase 2 | terminated | Nov 30, 2017 | Mario Negri Institute for Pharmacological Research | Low accrual rate | Enrollment / accrual |
| NCT01795365 | Active Surveillance of 2 Groups of Patients With Localized Prostate Cancer | N/A | terminated | Feb 20, 2013 | Centre Hospitalier Universitaire Vaudois | Participants are no longer being examined and receiving intervention. | Other (stated, no rule matched) |
| NCT02599909 | Gut Microbiota in People With Hepatocellular Carcinoma (HCC) | — | withdrawn | Nov 9, 2015 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT02967523 | Surefire Precision Infusion System Registry | — | terminated | Nov 18, 2016 | Surefire Medical, Inc. | not stated | Not stated |
| NCT03345225 | A Clinical Study of Precision TACE (P-TACE) With Surefire | N/A | withdrawn | Nov 17, 2017 | University of Miami | Funding | Funding |
| NCT02650635 | TLR8 Agonist VTX-2337 and Cyclophosphamide in Treating Patients With Metastatic,… | Phase 1 | terminated | Jan 8, 2016 | Mayo Clinic | permanently closed per sponsor's request | Other (stated, no rule matched) |
| NCT01425996 | A Dose-escalation Study of Lipotecan® Plus Radiotherapy in Locally Advanced… | Phase 1 / Phase 2 | terminated | Aug 30, 2011 | Taiwan Liposome Company | not stated | Not stated |
| NCT00527124 | Docetaxel and Prednisone With or Without Cediranib in Treating Patients With Metastatic… | Phase 2 | terminated | Sep 10, 2007 | National Cancer Institute (NCI) | Closure was recommended by CTEP due to slow accrual. | Enrollment / accrual |
| NCT01642095 | Studying Biomarkers in Samples From Younger Patients With Kidney Cancer | — | withdrawn | Jul 17, 2012 | Children's Oncology Group | not stated | Not stated |
| NCT02386111 | A Study of Varlilumab (Anti-CD27) and Sunitinib in Patients With Metastatic Clear Cell… | Phase 1 | terminated | Mar 11, 2015 | Celldex Therapeutics | Portfolio re-prioritization | Sponsor / business decision |
| NCT03326258 | Glembatumumab Vedotin, Nivolumab, and Ipilimumab in Treating Patients With Advanced… | Phase 1 / Phase 2 | withdrawn | Oct 31, 2017 | National Cancer Institute (NCI) | The study itself was Disapproved on 04/20/2018 and will not be moving forward. | Other (stated, no rule matched) |
| NCT01921751 | High or Standard Intensity Radiation Therapy After Gemcitabine Hydrochloride and… | Phase 2 | terminated | Aug 13, 2013 | Radiation Therapy Oncology Group | Trial would not be completed in a reasonable timeframe per CTEP guidelines | Other (stated, no rule matched) |
| NCT02345460 | Preoperative Folfirinox for Resectable Pancreatic Adenocarcinoma - A Phase II Study | Phase 2 | terminated | Jan 26, 2015 | Case Comprehensive Cancer Center | Competing studies | Other (stated, no rule matched) |
| NCT02943603 | A Study of Perioperative mFOLFOX6 Plus Pembrolizumab in Patients With Potentially… | Phase 2 | withdrawn | Oct 24, 2016 | Weijing Sun, MD, FACP | No participants enrolled. PI/Sponsor left UPitt. IND withdrawn \& revised protocol submitted… | Enrollment / accrual |
| NCT02491411 | Dexamethasone Prior to Re-treatment With Enzalutamide in Treating Patients With…(DEXTER) | N/A | terminated | Jul 8, 2015 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | The study is terminated due to lower enrollment | Enrollment / accrual |
| NCT02057874 | 3-Tesla MRI Response to TACE in HCC (Liver Cancer) | N/A | terminated | Feb 7, 2014 | Vanderbilt-Ingram Cancer Center | Funding unavailable | Funding |
| NCT02168179 | KeraStat Skin Therapy in Treating Radiation Dermatitis in Patients With Newly Diagnosed… | N/A | withdrawn | Jun 20, 2014 | Wake Forest University Health Sciences | No longer pursuing study at our site. | Other (stated, no rule matched) |
| NCT03045393 | Mirvetuximab Soravtansine (IMG853) in Folate Receptor Alpha-expressing TNBC(IMGN853) | Phase 1 | withdrawn | Feb 7, 2017 | Duke University | Inadequate enrollment | Enrollment / accrual |
| NCT01197664 | Paricalcitol, Fluorouracil, and Radiation Therapy in Treating Patients With Rectal Cancer… | Phase 1 | terminated | Sep 9, 2010 | Wake Forest University Health Sciences | Study terminated due to funding issues | Funding |
| NCT02023008 | Interactive Gentle Yoga in Improving Quality of Life in Patients With Stage I-III Breast… | N/A | terminated | Dec 30, 2013 | Wake Forest University Health Sciences | Study is not feasible | Other (stated, no rule matched) |
| NCT02423954 | Study of Nivolumab Plus Chemotherapy in Patients With Advanced Cancer (NivoPlus)(NivoPlus) | Phase 1 / Phase 2 | terminated | Apr 22, 2015 | Western Regional Medical Center | Investigator no longer at site to enroll patients or write up data | Investigator |
| NCT00832637 | Gemcitabine, Oxaliplatin, Tarceva &/or Cisplatin in HCC & Biliary Tree Cancers(Gem-ox) | Phase 2 | terminated | Jan 30, 2009 | New Mexico Cancer Research Alliance | Low accrual | Enrollment / accrual |
| NCT01482949 | A Rollover Protocol for Subjects Previously Treated With AGS-003 | Phase 2 | terminated | Dec 1, 2011 | Argos Therapeutics | Lack of efficacy | Efficacy / futility |
| NCT02215161 | Selinexor in Treating Patients With Abiraterone Acetate and/or Enzalutamide Refractory… | Phase 2 | terminated | Aug 13, 2014 | University of California, San Francisco | Risk to benefit ratio is not acceptable | Other (stated, no rule matched) |
| NCT02626754 | A Prospective Study on Sunitinib as First Line Therapy for Advanced/Metastatic Renal Cell… | Phase 2 | terminated | Dec 10, 2015 | vghtpe user | In most sites had difficult to recruitting subjects. | Enrollment / accrual |
| NCT03168152 | Randomized Trial Comparing Stereotactic Body Radiation Therapy to Microwave Ablation for… | N/A | withdrawn | May 30, 2017 | University of Michigan Rogel Cancer Center | No patients were accrued to the trial | Enrollment / accrual |
| NCT02748161 | DEB-TACE for Hepatocellular Carcinoma(QED) | N/A | terminated | Apr 22, 2016 | Surefire Medical, Inc. | Low enrollment | Enrollment / accrual |
| NCT03149159 | Investigator-Initiated Trial of Combined Ipilimumab, Nivolumab and Stereotactic Radiation… | Phase 2 | withdrawn | May 11, 2017 | Medical University of South Carolina | This study is withdrawn due to feasibility issues. | Other (stated, no rule matched) |
| NCT02702960 | Sequential, Related Donor Partial Liver Transplantation Followed by Bone Marrow… | Phase 2 | withdrawn | Mar 9, 2016 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | This study was withdrawn due to lack of necessary resources from the liver transplant surgical… | Other (stated, no rule matched) |
| NCT01582672 | Phase 3 Trial of Autologous Dendritic Cell Immunotherapy Plus Standard Treatment of…(ADAPT) | Phase 3 | terminated | Apr 23, 2012 | Argos Therapeutics | Lack of efficacy | Efficacy / futility |
| NCT00955305 | Paclitaxel, Carboplatin, and Bevacizumab With or Without Cixutumumab in Treating Patients… | Phase 2 | terminated | Aug 10, 2009 | National Cancer Institute (NCI) | The study was closed to accrual due to the end of the clinical development program with cixutumumab. | Enrollment / accrual |
| NCT00899093 | YKL-40 in Serum Samples From Patients With Newly Diagnosed Stage III-IV Ovarian… | — | terminated | May 12, 2009 | Gynecologic Oncology Group | not stated | Not stated |
| NCT01275664 | Granisetron, Aprepitant, and Dexamethasone in Preventing Nausea and Vomiting in Patients… | N/A | terminated | Jan 12, 2011 | Gynecologic Oncology Group | Study terminated due to no patient population available | Other (stated, no rule matched) |
| NCT02690350 | An Open Study Assessing the Safety and Tolerability of U3-1784 | Phase 1 | terminated | Feb 24, 2016 | Daiichi Sankyo | Program discontinued for business reasons (not safety). | Safety / toxicity |
| NCT01259024 | The LC Bead Trial; Transarterial Chemoembolization of Hepatocellular Carcinoma (HCC)With… | N/A | terminated | Dec 13, 2010 | Washington University School of Medicine | inability to obtain CMS approval | Other (stated, no rule matched) |
| NCT01887509 | Evaluation of Rectal Tumor Margin Using Confocal Endomicroscopy and Comparison to…(TRaMA) | N/A | terminated | Jun 27, 2013 | IHU Strasbourg | Difficulties with patients recruitment, study acceptance and protocol implementation. | Enrollment / accrual |
| NCT00003453 | Antineoplaston Therapy in Treating Patients With Stage IV Adrenal Gland Cancer | Phase 2 | terminated | Jan 27, 2003 | Burzynski Research Institute | Slow enrollment | Enrollment / accrual |
| NCT02543645 | A Study of Varlilumab and Atezolizumab in Patients With Advanced Cancer | Phase 1 | terminated | Sep 7, 2015 | Celldex Therapeutics | Portfolio re-prioritization | Sponsor / business decision |
| NCT02747173 | Assessment of Bone Biomarkers for TKI Response in RCC With Bone Metastases, HRQoL and…(METHEOS) | — | terminated | Apr 21, 2016 | Spanish Oncology Genito-Urinary Group | not stated | Not stated |
| NCT02379585 | Fasting on Newly Diagnosed Breast Cancer(STEFNE) | Phase 1 / Phase 2 | terminated | Mar 5, 2015 | Western Regional Medical Center | PI Decision | Other (stated, no rule matched) |
| NCT00459108 | Dasatinib in Treating Patients With Advanced Liver Cancer That Cannot Be Removed by… | Phase 2 | terminated | Apr 11, 2007 | National Cancer Institute (NCI) | Halted early for futility. | Efficacy / futility |
| NCT02149771 | Combination Treatment for Advanced Liver Cancer | Phase 3 | withdrawn | May 29, 2014 | Shanghai Zhongshan Hospital | Insufficient funding | Funding |
| NCT02365714 | CyberKnife Stereotactic Accelerated Partial Breast Irradiation (SAPBI)(CK-SAPBI) | Phase 1 / Phase 2 | terminated | Feb 19, 2015 | Georgetown University | Slow accrual | Enrollment / accrual |
| NCT02638909 | Study of Oral Ceritinib in Patients With ALK and ROS1 Activated Gastrointestinal… | Phase 2 | terminated | Dec 23, 2015 | Criterium, Inc. | Lack of Enrollment | Enrollment / accrual |
| NCT02365662 | A Study Evaluating Safety and Pharmacokinetics of ABBV-221 in Subjects With Advanced… | Phase 1 | terminated | Feb 19, 2015 | AbbVie | Safety | Safety / toxicity |
| NCT01359007 | FOLFIRINOX in Patients With Inoperable Pancreatic Cancer | Phase 2 | terminated | May 24, 2011 | University of Oklahoma | The principal investigator terminated the study due to inactivity and low enrollment | Investigator |
| NCT03456401 | Third Line TKI After 2 TKIs in Patients With mRCC (Tokio Study)(TOKIO) | Phase 2 | terminated | Mar 7, 2018 | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | availability of new and more promising therapeutic agents than expected in the experimentation in… | Other (stated, no rule matched) |
| NCT02962804 | Combination Radiation and PD-1 Inhibition in Metastatic or Recurrent Renal Cell Carcinoma… | Phase 2 | withdrawn | Nov 11, 2016 | University of Kansas Medical Center | Due to competing trials. Stopped before IRB approval. | Other (stated, no rule matched) |
| NCT01710293 | Intervention Protocol for Automated Point-of-Care Surveillance of Outpatient Delays in…(PACT CREATE 3) | N/A | withdrawn | Oct 19, 2012 | VA Office of Research and Development | Unable to obtain data needed to run the RCT; project never began recruitment | Enrollment / accrual |
| NCT02110953 | Irinotecan-Eluting Beads in Treating Patients With Refractory Metastatic Colon or Rectal… | Phase 1 | terminated | Apr 10, 2014 | Fox Chase Cancer Center | IRB study closure by investigator due to low enrollment | Investigator |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Oct 5, 2018source: clinicaltrials