Pediatric-inspired Regimen Combined With Venetoclax for Adolescent and Adult Patients With de Novo Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia

Inclusion Criteria:

* De novo and primary Ph/BCR-ABL1 negative acute lymphoblastic leukemia diagnosed by the bone marrow cytomorphology, immunophenotyping, cytogenetics and molecular biology according to WHO classification
* Age: 14 -60 years
* Male or female
* ECOG Performance Status 0-2
* Adequate end organ function as defined by: Total bilirubin ≤ 1.5 x upper limit of normal（ULN）; serum alanine aminotransferase (ALT) and serum aspartate aminotransferase (AST) ≤ 2.5 x ULN or ≤5 x ULN if leukemic involvement of the liver is present; Creatinine ≤ 1.5 x ULN; Serum amylase and lipase ≤ 1.5 x ULN; Alkaline phosphatase ≤ 2.5 x ULN unless considered tumor related; normal electrolytes: Potassium ≥ LLN; Magnesium ≥ LLN; Phosphorus ≥ LLN; Cardiac color Doppler ultrasound ejection fraction ≥ 45%;
* Subject has provided written informed consent prior to any screening procedure

Exclusion Criteria:

* Burkitt lymphoma/leukemia
* Acute Leukemia of Ambiguous Lineage
* Female patients who are pregnant or breast feeding
* Uncontrolled active serious infections that could, in the investigator's opinion, potentially interfere with the completion of treatment
* History of pancreatitis
* Poorly controlled diabetes, defined as glycosylated hemoglobin (HbA1c) values of \>7.5%. Patients with preexisting, well-controlled diabetes are not excluded
* History of active gastrointestinal bleeding within the last 6 months
* History of arterial/venous thrombosis within the last 6 months
* Known HIV seropositivity
* Any serious psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of treatment