Publication
SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma.
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- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerSynovial Sarcomacivic_curation1.00
- geneSSX1civic_curation1.00
- geneSSX2civic_curation1.00
- variantSSX1 Fusioncivic_curation1.00
- variantSSX2 Fusioncivic_curation1.00
Curated evidence
Evidence citing this paper (4)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 9428816
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| SSX1 Fusion2 | ||||||||
| (diagnostic) | Synovial Sarcoma | Diagnostic | B | Supports Positive | 3 | accepted | EID1065A characteristic SYT-SSX fusion gene resulting from the chromosomal translocation t(X;18)(p11;q11) is detectable in almost all synovial sarcomas. SYT (aka SS18) pairs with various 3' partners know as … (full text at CIViC) PMID 9428816 · Kawai et al., 1998 · Open in CIViC | civic |
| (prognostic) | Synovial Sarcoma | Prognostic | B | Supports Poor Outcome | 3 | accepted | EID1068In this study, SYT-SSX fusion transcripts (SS18-SSX1 and SS18-SSX2) were detected in 29 (64%) and 16 (36%) of the tumors, respectively. There was a significant relationship (P=0.003) between histologi… (full text at CIViC) PMID 9428816 · Kawai et al., 1998 · Open in CIViC | civic |
| SSX2 Fusion2 | ||||||||
| (diagnostic) | Synovial Sarcoma | Diagnostic | B | Supports Positive | 3 | accepted | EID1066A characteristic SYT-SSX fusion gene resulting from the chromosomal translocation t(X;18)(p11;q11) is detectable in almost all synovial sarcomas. SYT (aka SS18) pairs with various 3' partners know as … (full text at CIViC) PMID 9428816 · Kawai et al., 1998 · Open in CIViC | civic |
| (prognostic) | Synovial Sarcoma | Prognostic | B | Supports Better Outcome | 3 | accepted | EID1067In this study, SYT-SSX fusion transcripts (SS18-SSX1 and SS18-SSX2) were detected in 29 (64%) and 16 (36%) of the tumors, respectively. There was a significant relationship (P=0.003) between histologi… (full text at CIViC) PMID 9428816 · Kawai et al., 1998 · Open in CIViC | civic |