SSX2 Fusion

CI-VAR-00001177Explore in graph →CIViC 449

Curated evidence

Evidence by cancer (4 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–4 of 4 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Synovial Sarcoma4
SS18::SSX2 Fusion	(diagnostic)	Diagnostic	A	Supports Positive	4	accepted	EID1064 A t(X;18) is detected cytogenetically in over 90% of synovial sarcomas, regardless of histologic subtype. This translocation results primarily in two fusions. SYT-SSX1 (aka SS18-SSX1) and SYT-SSX2 (ak… (full text at CIViC) PMID 11607825 · Ladanyi, 2001 · Open in CIViC	civic
SS18::SSX2 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	3	accepted	EID1066 A characteristic SYT-SSX fusion gene resulting from the chromosomal translocation t(X;18)(p11;q11) is detectable in almost all synovial sarcomas. SYT (aka SS18) pairs with various 3' partners know as … (full text at CIViC) PMID 9428816 · Kawai et al., 1998 · Open in CIViC	civic
SS18::SSX2 Fusion

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.