Publication
Homologous recombination deficiency signatures in gastrointestinal and thoracic cancers correlate with platinum therapy duration.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 26, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260926-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerLung Adenocarcinomacivic_curation1.00
- drugCarboplatincivic_curation1.00
- drugGemcitabinecivic_curation1.00
- geneBARD1civic_curation1.00
- variantBARD1 G320*civic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-15
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 36964191
- Run
- ING-CIVIC-20260915-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| BARD1 G320*1 | ||||||||
| Carboplatin + GemcitabineCombination | Lung Adenocarcinoma | Predictive | C | Supports Sensitivity Response | 2 | accepted | EID13253A patient with lung adenocarcinoma harboring a somatic homozygous BARD1 G320* stop-gain alteration and an RBBP8 exon 3–4 duplication was classified as homologous recombination deficient by HRDetect an… (full text at CIViC) PMID 36964191 · Tsang et al., 2023 · Open in CIViC | civic |
| XRCC2 Deletion1 | ||||||||
| Platinum Compound | Gastrointestinal CarcinomaUNRESOLVED | Predictive | C | Supports Sensitivity Response | 2 | rejected | EID13254A patient with a gastrointestinal malignancy lacking BRCA1/2 alterations had a homozygous XRCC2 deletion, accompanied by loss of two of three XRCC3 copies, high HRD score (35), high SBS3 exposure (0.0… (full text at CIViC) PMID 36964191 · Tsang et al., 2023 · Open in CIViC | civic |