Variant · Deletion Cna
XRCC2 Deletion
CI-VAR-00417001Explore in graph →CIViC 5574
Curated evidence
Evidence by cancer (1 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-15
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 36964191
- Run
- ING-CIVIC-20260915-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Gastrointestinal Carcinoma1unmapped disease | ||||||||
| XRCC2 Deletion | Platinum Compound | Predictive | C | Supports Sensitivity Response | 2 | rejected | EID13254A patient with a gastrointestinal malignancy lacking BRCA1/2 alterations had a homozygous XRCC2 deletion, accompanied by loss of two of three XRCC3 copies, high HRD score (35), high SBS3 exposure (0.0… (full text at CIViC) PMID 36964191 · Tsang et al., 2023 · Open in CIViC | civic |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available
No ClinVar interpretation attached to this variant.