Publication
Transcriptome analysis offers a comprehensive illustration of the genetic background of pediatric acute myeloid leukemia.
Authors not recorded
Blood Adv2019PMID 31648321PMC6849955stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerAcute Myeloid Leukemia with NPM1-MLF1civic_curation1.00
- geneMLF1civic_curation1.00
- variantMLF1 Fusioncivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 31648321
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| MLF1 Fusion1 | ||||||||
| (diagnostic) | Acute Myeloid Leukemia with NPM1-MLF1ALIAS | Diagnostic | C | Supports Positive | 3 | accepted | EID12128In this 2019 study the authors aimed to detect the driver genetic alterations in a cohort of Japanese pediatric AML patients. Gene fusions were detected in 53/139 patients with RNA sequencing. The NPM… (full text at CIViC) PMID 31648321 · Shiba et al., 2019 · Open in CIViC | civic |