Publication

A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies.

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Science2019PMID 31395785PMC7327437stubpubmedPublished

Abstract

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Linked entities

Linked entities (6)

How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.

Validated 6

geneTP53civic_curation1.00
variantTP53 M237Icivic_curation1.00
variantTP53 R248Qcivic_curation1.00
variantTP53 R273Hcivic_curation1.00
variantTP53 R282Wcivic_curation1.00
variantTP53 Y220Ccivic_curation1.00

Curated evidence

Evidence citing this paper (7)

civicCuratedShowing 1–7 of 7 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
TP53 M237I1
(functional)	—UNRESOLVED	Functional	D	Does Not Support Neomorphic	4	accepted	EID7528 The M237I mutation was used to create isogenic AML cell lines using MOLM13 and K526 lines. M237I/- cells showed resistance to chemotherapeutic agents and failure to induce p21, indicating disruption o… (full text at CIViC) PMID 31395785 · Boettcher et al., 2019 · Open in CIViC	civic
TP53 R175H1
(functional)	—UNRESOLVED	Functional	D	Does Not Support Neomorphic	4	submitted	EID7526 The R175H mutation was used to create isogenic AML cell lines using MOLM13 and K526 lines. R175H/- cells showed resistance to chemotherapeutic agents and failure to induce p21, indicating disruption o… (full text at CIViC) PMID 31395785 · Boettcher et al., 2019 · Open in CIViC	civic
TP53 R248Q2
(functional)	—UNRESOLVED	Functional	D	Supports Dominant Negative	4	accepted	EID7525 CRISPR-Cas9 editing was used to create five isogenic MOLM13-TP53 AML cell lines with combinations of wild-type, mutant, and null TP53 alleles at the endogenous locus: p53+/+, p53+/-, p53-/-, R248Q/+, … (full text at CIViC) PMID 31395785 · Boettcher et al., 2019 · Open in CIViC	civic
〃	—UNRESOLVED	Functional	D	Does Not Support Neomorphic	4	accepted	EID7529 The R248Q mutation was used to create isogenic AML cell lines using MOLM13 and K526 lines. R248Q/- cells showed resistance to chemotherapeutic agents and failure to induce p21, indicating disruption o… (full text at CIViC) PMID 31395785 · Boettcher et al., 2019 · Open in CIViC	civic
TP53 R273H1
(functional)	—UNRESOLVED	Functional	D	Does Not Support Neomorphic	4	accepted	EID7530 The R273H mutation was used to create isogenic AML cell lines using MOLM13 and K526 lines. R273H/- cells showed resistance to chemotherapeutic agents and failure to induce p21, indicating disruption o… (full text at CIViC) PMID 31395785 · Boettcher et al., 2019 · Open in CIViC	civic
TP53 R282W1
(functional)	—UNRESOLVED	Functional	D	Does Not Support Neomorphic	3	accepted	EID7531 The R282W mutation was used to create isogenic AML cell lines using MOLM13 and K526 lines. R282W/- cells showed resistance to chemotherapeutic agents and failure to induce p21, indicating disruption o… (full text at CIViC) PMID 31395785 · Boettcher et al., 2019 · Open in CIViC	civic
TP53 Y220C1
(functional)	—UNRESOLVED	Functional	D	Does Not Support Neomorphic	4	accepted	EID7527 The Y220C mutation was used to create isogenic AML cell lines using MOLM13 and K526 lines. Y220C/- cells showed resistance to chemotherapeutic agents and failure to induce p21, indicating disruption o… (full text at CIViC) PMID 31395785 · Boettcher et al., 2019 · Open in CIViC	civic