Publication
Effectiveness of EGFR-TKIs in a Patient with Lung Adenocarcinoma Harboring an EGFR-RAD51 Fusion.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (6)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 6
- cancerLung Adenocarcinomacivic_curation1.00
- drugIcotinibcivic_curation1.00
- geneRAD51civic_curation1.00
- geneUSP42civic_curation1.00
- variantRAD51 Fusioncivic_curation1.00
- variantUSP42 Fusioncivic_curation1.00
Curated evidence
Evidence citing this paper (4)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 31064887
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| RAD51 Fusion1 | ||||||||
| Icotinib | Lung Adenocarcinoma | Predictive | C | Supports Sensitivity Response | 2 | accepted | EID7314A 26 year old non-smoker was diagnosed with lung adenocarcinoma and underwent thoracoscopic resection and treatment with cisplatin and pemetrexed. Panel NGS sequencing of the surgical sample detected … (full text at CIViC) PMID 31064887 · Guan et al., 2019 · Open in CIViC | civic |
| USP42 Fusion1 | ||||||||
| (oncogenic) | Lung Adenocarcinoma | Oncogenic | C | Supports Oncogenicity | 1 | accepted | EID12403One case with presumably EGFR::USP42 fusion was mentioned in OrigiMed database of Chinese patients with lung adenocarcinoma. EGFR breakpoint in intron 27. PMID 31064887 · Guan et al., 2019 · Open in CIViC | civic |
| ZNF713 Fusion1 | ||||||||
| (oncogenic) | Lung Adenocarcinoma | Oncogenic | C | Supports Oncogenicity | 1 | submitted | EID11156This is a case report of a patient with lung adenocarcinoma harboring EGFR::RAD51 fusion, however describes other EGFR fusions in lung adenocarcinoma. The authors examined data from the database of Or… (full text at CIViC) PMID 31064887 · Guan et al., 2019 · Open in CIViC | civic |
| YAP1 Fusion1 | ||||||||
| (oncogenic) | Lung Non-Small Cell CarcinomaCURATED_BROADER | Oncogenic | C | Supports Oncogenicity | 1 | submitted | EID11159An EGFR::YAP1 fusion was reported in a patient with non-small cell lung cancer. The breakpoint in EGFR is given as exon 26. Breakpoint in YAP1 is not specified. PMID 31064887 · Guan et al., 2019 · Open in CIViC | civic |