RAD51 Fusion

CI-VAR-00001217Explore in graph →CIViC 2203

Curated evidence

Evidence by cancer (10 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–10 of 10 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Lung Adenocarcinoma8
EGFR::RAD51 Fusion	Afatinib	Predictive	D	Supports Sensitivity Response	3	submitted	EID11019 Response to Afatinib was assessed by measuring viability of Ba/F3 cells expressing the EGFR::RAD51 variant 72 hours after treatment with Afatinib (10-1000 nmol/L). Viability was measured using the Cel… (full text at CIViC) PMID 27102076 · Konduri et al., 2016 · Open in CIViC	civic
EGFR::RAD51 Fusion	Erlotinib	Predictive	C	Supports Sensitivity Response	3	accepted	EID5909 A 48-year-old Chinese man with right lung tumor and multiple brain metastases of a lung adenocarcinoma (T1N2M1, stage IV). NGS analysis indicated an EGFR-RAD51 fusion rather than the most common kind… (full text at CIViC) PMID 29290255 · Zhu et al., 2018 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Lung Non-Small Cell Carcinoma1
EGFR::RAD51 Fusion	Gefitinib	Predictive	C	Supports Sensitivity Response	3	accepted	EID12371 A 37-year-old never smoker was diagnosed of pulmonary adenocarcinoma with mucinous pattern. FoundationOne DX1 panel detected an EGFR::RAD51 fusion and the patient was treated with first-line gefitinib… (full text at CIViC) PMID 35399574 · Di Federico et al., 2022 · Open in CIViC	civic

Unmapped disease1unmapped disease
EGFR::RAD51 Fusion	(functional)	Functional	D	Supports Gain Of Function	4	submitted	EID11016 Expression of EGFR::RAD51 via retroviral transfection in IL-3 dependent murine Ba/F3 cells results in activation of Pi3K/AKT pathway (Fig. 2C, increased levels of pAKT), and IL-3 independent prolifera… (full text at CIViC) PMID 27102076 · Konduri et al., 2016 · Open in CIViC	civic