Publication
HER kinase inhibition in patients with HER2- and HER3-mutant cancers.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerMalignant Bladder Neoplasmcivic_curation1.00
- drugNeratinibcivic_curation1.00
- geneERBB2civic_curation1.00
- variantERBB2 G292Rcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 29420467
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| ERBB2 G292R1 | ||||||||
| Neratinib | Malignant Bladder NeoplasmALIAS | Predictive | B | Does Not Support Sensitivity Response | 2 | accepted | EID12119In the SUMMIT basket trial (clinicaltrials.gov identifier NCT01953926) patients with solid tumors of various histologies harboring mutations of either HER2 or HER3 were enrolled and treated with the p… (full text at CIViC) PMID 29420467 · Hyman et al., 2018 · Open in CIViC | civic |
| ERBB2 V777L1 | ||||||||
| Neratinib | Malignant NeoplasmALIAS | Predictive | B | Does Not Support Sensitivity Response | 3 | submitted | EID12106In the SUMMIT basket trial (NCT01953926) patients with solid tumors of various histologies harboring mutations of either HER2 or HER3 were enrolled and treated with the pan-HER kinase inhibitor nerati… (full text at CIViC) PMID 29420467 · Hyman et al., 2018 · Open in CIViC | civic |