Publication
Ribociclib, a Cdk4/Cdk6 kinase inhibitor, enhances glucocorticoid sensitivity in B-acute lymphoblastic leukemia (B-All).
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
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Linked entities
Linked entities (8)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 8
- drugDexamethasonecivic_curation1.00
- drugRibociclibcivic_curation1.00
- geneCCND1civic_curation1.00
- geneCDK4civic_curation1.00
- geneCDK6civic_curation1.00
- variantCCND1 Overexpressioncivic_curation1.00
- variantCDK4 EXPRESSIONcivic_curation1.00
- variantCDK6 EXPRESSIONcivic_curation1.00
Curated evidence
Evidence citing this paper (5)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 29408328
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| CCND1 Overexpression1 | ||||||||
| (prognostic) | Childhood B-cell Acute Lymphoblastic LeukemiaUNRESOLVED | Prognostic | B | Supports Poor Outcome | 2 | accepted | EID8115Reverse phase protein array (RPPA) revealed upregulation of CCND1 at diagnosis in B-ALL relapse patients (n=27) versus patients that did not relapse (n=86, p>.01). 5-year cumulative incidence of relap… (full text at CIViC) PMID 29408328 · Bortolozzi et al., 2018 · Open in CIViC | civic |
| CDK4 EXPRESSION1 | ||||||||
| Dexamethasone + RibociclibCombination | Childhood B-cell Acute Lymphoblastic LeukemiaUNRESOLVED | Predictive | D | Supports Sensitivity Response | 2 | accepted | EID7798CDK4 was found to be significantly overexpressed in the bone marrow of MLL-rearranged B-ALL patients (n=70) compared to normal bone marrow (n=74, p<.001). Combination treatment with dexamethasone (glu… (full text at CIViC) PMID 29408328 · Bortolozzi et al., 2018 · Open in CIViC | civic |
| CDK4 Overexpression1 | ||||||||
| Dexamethasone + RibociclibCombination | Childhood B-cell Acute Lymphoblastic LeukemiaUNRESOLVED | Predictive | D | Supports Sensitivity Response | 3 | rejected | EID8114CDK4 was found to be significantly overexpressed in the bone marrow of MLL-rearranged B-ALL patients (n=70) compared to normal bone marrow (n=74, p<.001). Combination treatment with dexamethasone (glu… (full text at CIViC) PMID 29408328 · Bortolozzi et al., 2018 · Open in CIViC | civic |
| CDK6 EXPRESSION1 | ||||||||
| Dexamethasone + RibociclibCombination | Childhood B-cell Acute Lymphoblastic LeukemiaUNRESOLVED | Predictive | D | Supports Sensitivity Response | 2 | accepted | EID7801CDK6 was found to be significantly overexpressed in the bone marrow of B-ALL patients (n=299) compared to normal bone marrow (n=74, p<.001). Combination treatment with dexamethasone (glucocorticoid) a… (full text at CIViC) PMID 29408328 · Bortolozzi et al., 2018 · Open in CIViC | civic |
| CDK6 Overexpression1 | ||||||||
| Dexamethasone + RibociclibCombination | Childhood B-cell Acute Lymphoblastic LeukemiaUNRESOLVED | Predictive | D | Supports Sensitivity Response | 3 | rejected | EID8113CDK6 was found to be significantly overexpressed in the bone marrow of B-ALL patients (n=299) compared to normal bone marrow (n=74, p<.001). Combination treatment with dexamethasone (glucocorticoid) a… (full text at CIViC) PMID 29408328 · Bortolozzi et al., 2018 · Open in CIViC | civic |