Publication
Clinical significance of BRAF non-V600E mutations on the therapeutic effects of anti-EGFR monoclonal antibody treatment in patients with pretreated metastatic colorectal cancer: the Biomarker Research for anti-EGFR monoclonal Antibodies by Comprehensive Cancer genomics (BREAC) study.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerSolid Neoplasmcivic_curation1.00
- drugCetuximabcivic_curation1.00
- geneBRAFcivic_curation1.00
- variantBRAF L525Rcivic_curation1.00
Curated evidence
Evidence citing this paper (4)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 28972961
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| BRAF Q524L2 | ||||||||
| Cetuximab | Malignant NeoplasmALIAS | Predictive | D | Supports Sensitivity Response | 3 | submitted | EID12687BRAF mutants (Q524L, L525R, V600E) were transfected into HEK293 cells and downstream ERK phosphorylation was measured by western blot. Treatment with cetuximab reduced phosphorylation in wild-type and… (full text at CIViC) PMID 28972961 · Shinozaki et al., 2017 · Open in CIViC | civic |
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Gain Of Function | 3 | submitted | EID10017BRAF mutants (Q524L, L525R, V600E) were transfected into HEK293 cells and downstream ERK phosphorylation was measured by western blot. ERK phosphorylation induced by L525R was similar to that induced … (full text at CIViC) PMID 28972961 · Shinozaki et al., 2017 · Open in CIViC | civic |
| BRAF L525R2 | ||||||||
| Cetuximab | Solid NeoplasmCURATED_BROADER | Predictive | D | Supports Resistance | 3 | accepted | EID7560When transferred into EGFR expressing HEK293 cells, BRAF L525R induced increased ERK phosphorylation to a level similar to that induced by BRAF V600E. ERK phosphorylation enhanced by BRAF L525R was no… (full text at CIViC) PMID 28972961 · Shinozaki et al., 2017 · Open in CIViC | civic |
| (functional) | —UNRESOLVED | Functional | D | Supports Gain Of Function | 3 | accepted | EID7559When transferred into EGFR expressing HEK293 cells, BRAF L525R induced increased ERK phosphorylation to a level similar to that induced by BRAF V600E. PMID 28972961 · Shinozaki et al., 2017 · Open in CIViC | civic |