Publication
AKT Inhibition in Solid Tumors With AKT1 Mutations.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (6)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 6
- cancerMalignant Neoplasmcivic_curation1.00
- drugCapivasertibcivic_curation1.00
- geneAKT1civic_curation1.00
- genePIK3CAcivic_curation1.00
- variantAKT1 E17Kcivic_curation1.00
- variantPIK3CA Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 28489509
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| AKT1 E17K1 | ||||||||
| Capivasertib | Malignant NeoplasmALIAS | Predictive | B | Supports Sensitivity Response | 4 | accepted | EID3039AKT1 E17K mutations are oncogenic and occur in many cancers at a low prevalence. We performed a multihistology basket study of AZD5363. 58 patients with advanced solid tumors were treated. In patients… (full text at CIViC) PMID 28489509 · Hyman et al., 2017 · Open in CIViC | civic |
| PIK3CA Mutation1 | ||||||||
| Capivasertib | Malignant NeoplasmALIAS | Predictive | B | Supports Sensitivity Response | 4 | accepted | EID3040In a study of 37 patients with AKT1 (E13K) mutations, 5 patients harbored a concurrent PI3K/mTOR pathway alteration. The PFS of patients with a concurrent PI3K/mTOR pathway alteration was significantl… (full text at CIViC) PMID 28489509 · Hyman et al., 2017 · Open in CIViC | civic |