Publication
Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerMalignant Colorectal Neoplasmcivic_curation1.00
- genePOLEcivic_curation1.00
- variantPOLE P286Rcivic_curation1.00
- variantPOLE S459Fcivic_curation1.00
- variantPOLE V411Lcivic_curation1.00
Curated evidence
Evidence citing this paper (3)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 28404093
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| POLE P286R1 | ||||||||
| (prognostic) | Malignant Colorectal NeoplasmCURATED_BROADER | Prognostic | B | Supports Better Outcome | 3 | accepted | EID5017POLE proofreading domain mutations identify a subset of immunogenic colorectal cancers with excellent prognosis. PMID 28404093 · Domingo et al., 2016 · Open in CIViC | civic |
| POLE S459F1 | ||||||||
| (prognostic) | Malignant Colorectal NeoplasmCURATED_BROADER | Prognostic | B | Supports Better Outcome | 3 | accepted | EID5019POLE proofreading domain mutations identify a subset of immunogenic colorectal cancers with excellent prognosis. PMID 28404093 · Domingo et al., 2016 · Open in CIViC | civic |
| POLE V411L1 | ||||||||
| (prognostic) | Malignant Colorectal NeoplasmCURATED_BROADER | Prognostic | B | Supports Better Outcome | 3 | accepted | EID5018POLE proofreading domain mutations identify a subset of immunogenic colorectal cancers with excellent prognosis. PMID 28404093 · Domingo et al., 2016 · Open in CIViC | civic |