POLE V411L

CI-VAR-00004526Explore in graph →CIViC 1831

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Colorectal Neoplasm2
POLE V411L	(prognostic)	Prognostic	B	Supports Better Outcome	3	accepted	EID5018 POLE proofreading domain mutations identify a subset of immunogenic colorectal cancers with excellent prognosis. PMID 28404093 · Domingo et al., 2016 · Open in CIViC	civic
POLE V411L	Unspecified therapy	Predictive	C	Supports Sensitivity Response	2	submitted	EID8631 "CRCs with POLE proofreading deficiency had characteristics distinct from those of other CRCs. Analysis of POLE proofreading deficiency may be clinically significant for personalized management of CRC… (full text at CIViC) PMID 31240875 · Hino et al., 2019 · Open in CIViC	civic
Unmapped disease1

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.