Publication
High-throughput Phenotyping of Lung Cancer Somatic Mutations.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (8)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 8
- cancerMalignant Lung Neoplasmcivic_curation1.00
- geneARAFcivic_curation1.00
- geneEGFRcivic_curation1.00
- variantARAF S214Ccivic_curation1.00
- variantARAF S214Fcivic_curation1.00
- variantARAF V145Lcivic_curation1.00
- variantEGFR K754Ecivic_curation1.00
- variantEGFR S645Ccivic_curation1.00
Curated evidence
Evidence citing this paper (5)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 27478040
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| ARAF S214C1 | ||||||||
| (oncogenic) | Malignant Lung Neoplasm | Oncogenic | D | Supports Oncogenicity | 3 | accepted | EID11147194 somatic mutations seen in primary lung cancers were functionally evaluated using three approaches: (1) differences in pattern or extent of changes in gene expression in A549 cells induced by trans… (full text at CIViC) PMID 27478040 · Berger et al., 2016 · Open in CIViC | civic |
| ARAF S214F1 | ||||||||
| (oncogenic) | Malignant Lung Neoplasm | Oncogenic | D | Supports Oncogenicity | 3 | accepted | EID11146194 somatic mutations seen in primary lung cancers were functionally evaluated using three approaches: (1) differences in pattern or extent of changes in gene expression in A549 cells induced by trans… (full text at CIViC) PMID 27478040 · Berger et al., 2016 · Open in CIViC | civic |
| ARAF V145L1 | ||||||||
| (oncogenic) | Malignant Lung Neoplasm | Oncogenic | D | Does Not Support Oncogenicity | 3 | accepted | EID11148194 somatic mutations seen in primary lung cancers were functionally evaluated using three approaches: (1) differences in pattern or extent of changes in gene expression in A549 cells induced by trans… (full text at CIViC) PMID 27478040 · Berger et al., 2016 · Open in CIViC | civic |
| EGFR K754E1 | ||||||||
| (oncogenic) | Malignant Lung Neoplasm | Oncogenic | D | Supports Oncogenicity | 3 | accepted | EID11145194 somatic mutations seen in primary lung cancers were functionally evaluated using three approaches: (1) differences in pattern or extent of changes in gene expression in A549 cells induced by trans… (full text at CIViC) PMID 27478040 · Berger et al., 2016 · Open in CIViC | civic |
| EGFR S645C1 | ||||||||
| (oncogenic) | Malignant Lung Neoplasm | Oncogenic | D | Supports Oncogenicity | 3 | accepted | EID11144194 somatic mutations seen in primary lung cancers were functionally evaluated using three approaches: (1) differences in pattern or extent of changes in gene expression in A549 cells induced by trans… (full text at CIViC) PMID 27478040 · Berger et al., 2016 · Open in CIViC | civic |