ARAF S214F

CI-VAR-00004021Explore in graph →CIViC 4410

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Lung Neoplasm1
ARAF S214F	(oncogenic)	Oncogenic	D	Supports Oncogenicity	3	accepted	EID11146 194 somatic mutations seen in primary lung cancers were functionally evaluated using three approaches: (1) differences in pattern or extent of changes in gene expression in A549 cells induced by trans… (full text at CIViC) PMID 27478040 · Berger et al., 2016 · Open in CIViC	civic
Unmapped disease1unmapped disease
ARAF S214F	(functional)	Functional	B	Supports Gain Of Function	5	accepted	EID12972 Imielinski et al displays functional evidence (Figure 3A) showing the S214F variant causes increased colony formation and increased pMEK/MEK ratio. PMID 24569458 · Imielinski et al., 2014 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.