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CRAF R391W is a melanoma driver oncogene.

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Sci Rep2016PMID 27273450PMC4897636stubpubmedProvenance
Source
PubMed
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-CIVIC-20260908-000001
Published

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Linked entities

Linked entities (2)

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Validated 2

Curated evidence

Evidence citing this paper (2)

civicProvenance
Source
CIViC — Clinical Interpretation of Variants in Cancer
Dataset
CIViC evidence items
Version
civic-2026-09-08
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Evidence
expert curation
License
CC0 1.0
PMID
27273450
Run
ING-CIVIC-20260908-000001
Open at source CuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.
TherapyCancerTypeLevelDirection · significanceRating (1–5)StatusEvidenceSource
RAF1 R391W2
VemurafenibMelanomaPredictiveDSupports Resistance—submitted
EID4824

In an in vitro study, M375 and M238 cell lines expressing RAF1 (CRAF) R391W demonstrated resistant to vemurafenib treatment compared to M397 cells expressing BRAF V600E (a known vemurafenib sensitizin… (full text at CIViC)

PMID 27273450 · Atefi et al., 2016 · Open in CIViC

civic
(functional)—UNRESOLVEDFunctionalDSupports Gain Of Function3accepted
EID11044

RAF1 (CRAF) R391W was observed in a melanoma patient from which cell line M375 was derived (wild-type for BRAF and NRAS). RAF1 R391W expressed in 293T cells showed increased phosphorylation of MEK and… (full text at CIViC)

PMID 27273450 · Atefi et al., 2016 · Open in CIViC

civic