Publication
Targeting mutant NRAS signaling pathways in melanoma.
Authors not recorded
Pharmacol Res2016PMID 26987942PMC4867277stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerCutaneous Melanomacivic_curation1.00
- drugBinimetinibcivic_curation1.00
- drugRibociclibcivic_curation1.00
- geneNRAScivic_curation1.00
- variantNRAS Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 26987942
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| NRAS Mutation1 | ||||||||
| Binimetinib + RibociclibCombination | Cutaneous MelanomaALIAS | Predictive | B | Supports Sensitivity Response | 3 | accepted | EID2931Inhibition of CDK4 and 6, regulators of the G1/S cell cycle checkpoint, arrests the cell cycle in the G1 phase, suppresses DNA synthesis, and inhibits cancer cell growth. There is an ongoing phase 1/2… (full text at CIViC) PMID 26987942 · Vu et al., 2016 · Open in CIViC | civic |