Publication
Activating JAK1 mutation may predict the sensitivity of JAK-STAT inhibition in hepatocellular carcinoma.
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- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerHepatocellular Carcinomacivic_curation1.00
- drugRuxolitinibcivic_curation1.00
- geneJAK1civic_curation1.00
- variantJAK1 S703Icivic_curation1.00
Curated evidence
Evidence citing this paper (9)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 26701727
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| JAK1 A1086S2 | ||||||||
| Ruxolitinib | Hepatocellular Carcinoma | Predictive | D | Does Not Support Sensitivity Response | 3 | submitted | EID10058JAK1 mutations were identified by sequencing 60 HCC PDX tumour models. There mutations were then functionally characterized. HEK293FT cells were transfected with JAK1 WT or mutants (N451S, E483D, S703… (full text at CIViC) PMID 26701727 · Yang et al., 2016 · Open in CIViC | civic |
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Gain Of Function | 3 | submitted | EID10055HEK293FT cells were transfected with JAK1 WT or mutants (N451S, E483D, S703I, A1086S, S729C) following which phosphorylation of JAK1, STAT3 and STAT5 were measured. Both the known activating mutation … (full text at CIViC) PMID 26701727 · Yang et al., 2016 · Open in CIViC | civic |
| JAK1 E483D2 | ||||||||
| Ruxolitinib | Hepatocellular Carcinoma | Predictive | D | Does Not Support Sensitivity Response | 3 | submitted | EID10057JAK1 mutations were identified by sequencing 60 HCC PDX tumour models. There mutations were then functionally characterized. HEK293FT cells were transfected with JAK1 WT or mutants (N451S, E483D, S703… (full text at CIViC) PMID 26701727 · Yang et al., 2016 · Open in CIViC | civic |
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Gain Of Function | 3 | submitted | EID10054HEK293FT cells were transfected with JAK1 WT or mutants (N451S, E483D, S703I, A1086S, S729C) following which phosphorylation of JAK1, STAT3 and STAT5 were measured. Both the known activating mutation … (full text at CIViC) PMID 26701727 · Yang et al., 2016 · Open in CIViC | civic |
| JAK1 N451S2 | ||||||||
| Ruxolitinib | Hepatocellular Carcinoma | Predictive | D | Does Not Support Sensitivity Response | 3 | submitted | EID10056JAK1 mutations were identified by sequencing 60 HCC PDX tumour models. There mutations were then functionally characterized. HEK293FT cells were transfected with JAK1 WT or mutants (N451S, E483D, S703… (full text at CIViC) PMID 26701727 · Yang et al., 2016 · Open in CIViC | civic |
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Gain Of Function | 3 | submitted | EID10053HEK293FT cells were transfected with JAK1 WT or mutants (N451S, E483D, S703I, A1086S, S729C) following which phosphorylation of JAK1, STAT3 and STAT5 were measured. Both the known activating mutation … (full text at CIViC) PMID 26701727 · Yang et al., 2016 · Open in CIViC | civic |
| JAK1 S703I2 | ||||||||
| Ruxolitinib | Hepatocellular Carcinoma | Predictive | D | Supports Sensitivity Response | 4 | accepted | EID1900A JAK1 S703I mutation was found to activate the JAK-STAT signaling pathway in vitro and in vivo in hepatocellular carcinoma. Ruxolitinib causes the suppression of JAK-STAT signaling pathway in PDX mod… (full text at CIViC) PMID 26701727 · Yang et al., 2016 · Open in CIViC | civic |
| (functional) | —UNRESOLVED | Functional | D | Supports Gain Of Function | 3 | submitted | EID10051HEK293FT cells were transfected with JAK1 WT or mutants (N451S, E483D, S703I, A1086S, S729C) following which phosphorylation of JAK1, STAT3 and STAT5 were measured. Both the known activating mutation … (full text at CIViC) PMID 26701727 · Yang et al., 2016 · Open in CIViC | civic |
| JAK1 S729C1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Gain Of Function | 3 | submitted | EID10052HEK293FT cells were transfected with JAK1 WT or mutants (N451S, E483D, S703I, A1086S, S729C) following which phosphorylation of JAK1, STAT3 and STAT5 were measured. Both the known activating mutation … (full text at CIViC) PMID 26701727 · Yang et al., 2016 · Open in CIViC | civic |