Publication
Varying responses of PML-RARA with different genetic mutations to arsenic trioxide.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
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Linked entities
Linked entities (6)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 6
- cancerAcute Promyelocytic Leukemiacivic_curation1.00
- drugArsenic Trioxidecivic_curation1.00
- genePMLcivic_curation1.00
- geneRARAcivic_curation1.00
- variantPML A216Vcivic_curation1.00
- variantRARA Fusioncivic_curation1.00
Curated evidence
Evidence citing this paper (3)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 26537301
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| PML A216T + RARA FusionRARAPML1 | ||||||||
| Arsenic Trioxide | Acute Promyelocytic Leukemia | Predictive | B | Supports Resistance | 4 | submitted | EID8179ive point mutations were identified in the PML B2 domain of PML-RARA transcripts in 9 patients diagnosed with APL and resistant to arsenic. DNA from these patients was amplified using polymerase chain… (full text at CIViC) PMID 26537301 · Liu et al., 2016 · Open in CIViC | civic |
| PML A216V + RARA FusionRARAPML1 | ||||||||
| Arsenic Trioxide | Acute Promyelocytic Leukemia | Predictive | B | Supports Resistance | 4 | accepted | EID8177Five point mutations were identified in the PML B2 domain of PML-RARA transcripts in 9 patients diagnosed with APL and resistant to arsenic. DNA from these 9 patients was cloned into flag-tagged pCag … (full text at CIViC) PMID 26537301 · Liu et al., 2016 · Open in CIViC | civic |
| RARA Fusion + PML S214LRARAPML1 | ||||||||
| Arsenic Trioxide | Acute Promyelocytic Leukemia | Predictive | B | Supports Resistance | 4 | submitted | EID8178Five point mutations were identified in the PML B2 domain of PML-RARA transcripts in 9 patients diagnosed with APL and resistant to arsenic. DNA from these 9 patients was cloned into flag-tagged pCag … (full text at CIViC) PMID 26537301 · Liu et al., 2016 · Open in CIViC | civic |