Publication
Alternative transcription initiation leads to expression of a novel ALK isoform in cancer.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerCutaneous Melanomacivic_curation1.00
- drugCrizotinibcivic_curation1.00
- geneALKcivic_curation1.00
- variantALK Alternative Transcript (ATI)civic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 26444240
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| ALK Alternative Transcript (ATI)2 | ||||||||
| Crizotinib | Cutaneous MelanomaALIAS | Predictive | C | Supports Sensitivity Response | 4 | accepted | EID1936Expression of an alternative ALK transcript (ATI), encompassing exons 20–29 preceded by ~400 base pairs (bp) of intron 19, but not exons 1–19 was identified in three samples of thyroid cancer and mela… (full text at CIViC) PMID 26444240 · Wiesner et al., 2015 · Open in CIViC | civic |
| 〃 | Malignant NeoplasmALIAS | Predictive | D | Supports Sensitivity Response | 4 | submitted | EID7646Expression of the ALK alternative transcript isoform (ATI) in Ba/F3 cells resulted in phosphorylation of ALK and IL3-independent growth in vitro, while ALK ATI expressing NIH-3T3 cells induced tumorig… (full text at CIViC) PMID 26444240 · Wiesner et al., 2015 · Open in CIViC | civic |