Publication
CD44 Isoform Status Predicts Response to Treatment with Anti-CD44 Antibody in Cancer Patients.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerMalignant Neoplasmcivic_curation1.00
- drugRG7356civic_curation1.00
- geneCD44civic_curation1.00
- variantCD44 CD44s Expressioncivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 25762343
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| CD44 CD44s Expression1 | ||||||||
| RG7356 | Malignant NeoplasmALIAS | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID825CD44 isoform expression (especially CD44s) was identified to predict response to CD44 antibody RG7356 preclinically. Retrospective evaluation of 13 patients from a phase 1 study, treated with RG7356, … (full text at CIViC) PMID 25762343 · Birzele et al., 2015 · Open in CIViC | civic |
| CD44 CD44v3-v10 + CD44 CD44v8-v101 | ||||||||
| RG7356 | Malignant NeoplasmALIAS | Predictive | B | Supports Resistance | 4 | submitted | EID9395In RG7356 xenograft models, cell lines expressing predominantly a mixture of CD44v8-v10 and CD44v3-v10 show no response to treatment with RG7356 measured as a percentage of tumor growth inhibition. In… (full text at CIViC) PMID 25762343 · Birzele et al., 2015 · Open in CIViC | civic |