Publication
MDM2 is an important prognostic and predictive factor for platin-pemetrexed therapy in malignant pleural mesotheliomas and deregulation of P14/ARF (encoded by CDKN2A) seems to contribute to an MDM2-driven inactivation of P53.
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- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerPleural Malignant Mesotheliomacivic_curation1.00
- drugCisplatincivic_curation1.00
- drugPemetrexedcivic_curation1.00
- geneMDM2civic_curation1.00
- variantMDM2 EXPRESSIONcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 25668009
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| MDM2 EXPRESSION2 | ||||||||
| (prognostic) | Pleural Malignant MesotheliomaALIAS | Prognostic | B | Supports Poor Outcome | 3 | accepted | EID82872 patients with malignant pleural mesothelioma were analyzed, MDM2 immunoexpression was assessed in 65 patients. MDM2 mRNA and protein expression correlated with poor OS and PFS for patients treated … (full text at CIViC) PMID 25668009 · Walter et al., 2015 · Open in CIViC | civic |
| Cisplatin + PemetrexedCombination | Pleural Malignant MesotheliomaALIAS | Predictive | B | Supports Resistance | 1 | accepted | EID82772 patients with malignant pleural mesothelioma were analyzed, MDM2 immunoexpression was assessed in 65 patients. MDM2 mRNA and protein expression correlated with poor OS and PFS for patients treated … (full text at CIViC) PMID 25668009 · Walter et al., 2015 · Open in CIViC | civic |