Publication
Neuregulin 1 expression is a predictive biomarker for response to AV-203, an ERBB3 inhibitory antibody, in human tumor models.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
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Linked entities
Linked entities (6)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 6
- cancerMalignant Neoplasmcivic_curation1.00
- drugAnti-ErbB3 Monoclonal Antibody AV-203civic_curation1.00
- geneERBB3civic_curation1.00
- geneNRG1civic_curation1.00
- variantERBB3 EXPRESSIONcivic_curation1.00
- variantNRG1 Expressioncivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 25542901
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| ERBB3 EXPRESSION1 | ||||||||
| Anti-ErbB3 Monoclonal Antibody AV-203 | Malignant NeoplasmALIAS | Predictive | D | Does Not Support Sensitivity Response | 3 | accepted | EID862The authors conducted an in vivo efficacy study of AV-203 (ERBB3 inhibitory antibody) using a panel of 32 xenograft models representing 12 human cancer types. To identify biomarkers that can predict r… (full text at CIViC) PMID 25542901 · Meetze et al., 2015 · Open in CIViC | civic |
| NRG1 Expression1 | ||||||||
| Anti-ErbB3 Monoclonal Antibody AV-203 | Malignant NeoplasmALIAS | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID861This screening study in various tumor xenografts identified NRG1 expression to correlate with sensivity to ERBB3 inhibitory antibody AV-203. ERBB3 expression was not predictive of response. PMID 25542901 · Meetze et al., 2015 · Open in CIViC | civic |