Publication
p27 and BCL2 expression predicts response to chemotherapy in head and neck squamous cell carcinomas.
Authors not recorded
Oral Oncol2014PMID 24239278stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerHead and Neck Squamous Cell Carcinomacivic_curation1.00
- drugCisplatincivic_curation1.00
- drugFluorouracilcivic_curation1.00
- geneCDKN1Bcivic_curation1.00
- variantCDKN1B EXPRESSIONcivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 24239278
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| CDKN1B EXPRESSION1 | ||||||||
| Cisplatin + FluorouracilCombination | Head and Neck Squamous Cell Carcinoma | Predictive | B | Supports Sensitivity Response | 2 | accepted | EID88941 HNSSC were analyzed by IHC for expression of EGFR, p53, CCND1, p16, p21, p27 (CDKN2B), p-AKT, HIF-1a, Caspase 3 and BCL2. p27 was the only protein that served as a predictive biomarker of response … (full text at CIViC) PMID 24239278 · Moreno-Galindo et al., 2014 · Open in CIViC | civic |