PDGFRA G853D

CI-VAR-00001841Explore in graph →NP_006197.1:p.Gly853AspNM_006206.4:c.2558G>AClinVar 376185 CIViC 865 rs763576329

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Melanoma1
PDGFRA G853D	Crenolanib + ImatinibSubstitutes	Predictive	D	Supports Sensitivity Response	3	accepted	EID1977 PDGFRA mutations (exon 12, 14, 18) were assessed in 351 melanoma patient samples. 18 different mutations were detected in 4,6% of samples (all without chronic sun-induced damage and mainly in acral an… (full text at CIViC) PMID 24132921 · Dai et al., 2013 · Open in CIViC	civic

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
376185	Uncertain significance	criteria provided, multiple submitters, no conflicts	2	Gastrointestinal stromal tumor; Hereditary cancer-predisposing syndrome	germline	2	Apr 02, 2025	clinvar