Publication
Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (8)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 8
- cancerHead and Neck Squamous Cell Carcinomacivic_curation1.00
- cancerLung Squamous Cell Carcinomacivic_curation1.00
- drugPazopanibcivic_curation1.00
- geneFGFR2civic_curation1.00
- geneFGFR3civic_curation1.00
- variantFGFR2 P253Rcivic_curation1.00
- variantFGFR2 W290Ccivic_curation1.00
- variantFGFR3 S249Ccivic_curation1.00
Curated evidence
Evidence citing this paper (6)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 23786770
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| FGFR2 P253R1 | ||||||||
| Pazopanib | Head and Neck Squamous Cell Carcinoma | Predictive | C | Supports Sensitivity Response | 3 | accepted | EID7833FGFR2 p.P253R mutation detected in patient with head and neck SCC. Mutation initially detected by RNA-Seq and confirmed by Sanger sequencing. Patient is 52 y/o male with initial diagnosis of SCC of … (full text at CIViC) PMID 23786770 · Liao et al., 2013 · Open in CIViC | civic |
| FGFR2 K660E1 | ||||||||
| (oncogenic) | Lung Squamous Cell Carcinoma | Oncogenic | D | Supports Oncogenicity | 3 | submitted | EID7939NIH-3T3 cells with the FGFR2 K660E kinase domain mutation demonstrated an increase in colony formation relative to wild-type in an anchorage-independence assay, which was lost with the introduction of… (full text at CIViC) PMID 23786770 · Liao et al., 2013 · Open in CIViC | civic |
| FGFR2 S320C1 | ||||||||
| (oncogenic) | Lung Squamous Cell Carcinoma | Oncogenic | D | Supports Oncogenicity | 3 | submitted | EID7938NIH-3T3 cells with the FGFR2 S320C extracellular domain mutation demonstrated an increase in colony formation in an anchorage-independence assay, which was lost with the introduction of AP24534, BGJ39… (full text at CIViC) PMID 23786770 · Liao et al., 2013 · Open in CIViC | civic |
| FGFR2 W290C1 | ||||||||
| (oncogenic) | Lung Squamous Cell Carcinoma | Oncogenic | D | Supports Oncogenicity | 3 | accepted | EID7937NIH-3T3 cells with the FGFR2 W290C extracellular domain mutation demonstrated an increase in colony formation in an anchorage independent growth assay, which was lost with the introduction of AP24534,… (full text at CIViC) PMID 23786770 · Liao et al., 2013 · Open in CIViC | civic |
| FGFR3 R248C1 | ||||||||
| (oncogenic) | Lung Squamous Cell Carcinoma | Oncogenic | D | Supports Oncogenicity | 3 | submitted | EID7940NIH-3T3 cells with the FGFR3 R248C extracellular domain mutation demonstrated an increase in colony formation compared to wild-type in an anchorage-independence assay, which was counteracted by treatm… (full text at CIViC) PMID 23786770 · Liao et al., 2013 · Open in CIViC | civic |
| FGFR3 S249C1 | ||||||||
| (oncogenic) | Lung Squamous Cell Carcinoma | Oncogenic | D | Supports Oncogenicity | 3 | accepted | EID7941NIH-3T3 cells with the FGFR3 S249C extracellular domain mutation demonstrated an increase in colony formation compared to wild-type in an anchorage-independence assay, which was counteracted by the tr… (full text at CIViC) PMID 23786770 · Liao et al., 2013 · Open in CIViC | civic |