Publication
Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
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Linked entities
Linked entities (10)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 10
- cancerAcute Lymphoblastic Leukemiacivic_curation1.00
- cancerT Acute Lymphoblastic Leukemiacivic_curation1.00
- drugArabinosylguaninecivic_curation1.00
- drugMercaptopurinecivic_curation1.00
- drugNelarabinecivic_curation1.00
- drugThioguaninecivic_curation1.00
- geneNT5C2civic_curation1.00
- variantNT5C2 D407Acivic_curation1.00
- variantNT5C2 K359Qcivic_curation1.00
- variantNT5C2 R367Qcivic_curation1.00
Curated evidence
Evidence citing this paper (8)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 23377281
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| NT5C2 K359Q3 | ||||||||
| (prognostic) | Acute Lymphoblastic Leukemia | Prognostic | B | Supports Poor Outcome | 4 | accepted | EID667The K359Q somatic mutation was significantly correlated with early disease recurrence and relapse in 103 T-cell ALL regardless of treatment course. The data was obtained from Berlin Frankfurt Münster … (full text at CIViC) PMID 23377281 · Tzoneva et al., 2013 · Open in CIViC | civic |
| Arabinosylguanine + NelarabineSubstitutes | T Acute Lymphoblastic LeukemiaCURATED_BROADER | Predictive | D | Does Not Support Resistance | 4 | accepted | EID636CCRF-CEM and CUTLL1 T-ALL cell lines expressing NT5C2 mutant proteins (K359Q, R367Q or D407A) observed in relapsed T-ALL patients showed no difference in sensitivity to nelarabine or arabinosylguanine… (full text at CIViC) PMID 23377281 · Tzoneva et al., 2013 · Open in CIViC | civic |
| Mercaptopurine + ThioguanineSubstitutes | T Acute Lymphoblastic LeukemiaCURATED_BROADER | Predictive | D | Supports Resistance | 4 | accepted | EID631CCRF-CEM and to a lesser extent CUTLL1 T-ALL cell lines expressing the NT5C2 K359Q mutation had increased resistance to 6-mercaptopurine and 6-thioguanine treatment than cells expressing wildtype NT5C… (full text at CIViC) PMID 23377281 · Tzoneva et al., 2013 · Open in CIViC | civic |
| NT5C2 D407A2 | ||||||||
| Mercaptopurine + ThioguanineSubstitutes | T Acute Lymphoblastic LeukemiaCURATED_BROADER | Predictive | D | Supports Resistance | 4 | accepted | EID632CCRF-CEM and to a lesser extent CUTLL1 T-ALL cell lines expressing the NT5C2 D407A mutation had increased resistance to 6-mercaptopurine and 6-thioguanine treatment than cells expressing wildtype NT5C… (full text at CIViC) PMID 23377281 · Tzoneva et al., 2013 · Open in CIViC | civic |
| Arabinosylguanine + NelarabineSubstitutes | T Acute Lymphoblastic LeukemiaCURATED_BROADER | Predictive | D | Does Not Support Resistance | 4 | accepted | EID635CCRF-CEM and CUTLL1 T-ALL cell lines expressing NT5C2 mutant proteins (K359Q, R367Q or D407A) observed in relapsed T-ALL patients showed no difference in sensitivity to nelarabine or arabinosylguanine… (full text at CIViC) PMID 23377281 · Tzoneva et al., 2013 · Open in CIViC | civic |
| NT5C2 R367Q3 | ||||||||
| Mercaptopurine + ThioguanineSubstitutes | T Acute Lymphoblastic LeukemiaCURATED_BROADER | Predictive | D | Supports Resistance | 4 | accepted | EID630CCRF-CEM and to a lesser extent CUTLL1 T-ALL cell lines expressing the NT5C2 R367Q mutation had increased resistance to 6-mercaptopurine and 6-thioguanine treatment than cells expressing wildtype NT5C… (full text at CIViC) PMID 23377281 · Tzoneva et al., 2013 · Open in CIViC | civic |
| Arabinosylguanine + NelarabineSubstitutes | T Acute Lymphoblastic LeukemiaCURATED_BROADER | Predictive | C | Supports Sensitivity Response | 4 | rejected | EID634CCRF-CEM and CUTLL1 T-ALL cell lines expressing NT5C2 mutant proteins (R367Q, R359Q or D407A) observed in relapsed T-ALL patients showed no difference in sensitivity to nelarabine or arabinosylguanine… (full text at CIViC) PMID 23377281 · Tzoneva et al., 2013 · Open in CIViC | civic |
| 〃 | T Acute Lymphoblastic LeukemiaCURATED_BROADER | Predictive | D | Does Not Support Resistance | 4 | accepted | EID633CCRF-CEM and CUTLL1 T-ALL cell lines expressing NT5C2 mutant proteins (K359Q, R367Q or D407A) observed in relapsed T-ALL patients showed no difference in sensitivity to nelarabine or arabinosylguanine… (full text at CIViC) PMID 23377281 · Tzoneva et al., 2013 · Open in CIViC | civic |