Publication
Upregulation of the antiapoptotic factor Livin contributes to cisplatin resistance in colon cancer cells.
Authors not recorded
Tumour Biol2013PMID 23188704stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerMalignant Colon Neoplasmcivic_curation1.00
- drugCisplatincivic_curation1.00
- geneBIRC7civic_curation1.00
- variantBIRC7 Amplificationcivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 23188704
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| BIRC7 Amplification1 | ||||||||
| Cisplatin | Malignant Colon Neoplasm | Predictive | D | Supports Resistance | 4 | accepted | EID661Livin (BIRC7) overexpression in two colon cancer cell lines (RKO and SW620) increased resistance of these cells to cisplatin. siRNA knockdown of Livin rendered the cells more sensitive to cisplatin. T… (full text at CIViC) PMID 23188704 · Ding et al., 2013 · Open in CIViC | civic |