BIRC7 Amplification

CI-VAR-00000204Explore in graph →CIViC 251

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Colon Neoplasm1
BIRC7 Amplification	Cisplatin	Predictive	D	Supports Resistance	4	accepted	EID661 Livin (BIRC7) overexpression in two colon cancer cell lines (RKO and SW620) increased resistance of these cells to cisplatin. siRNA knockdown of Livin rendered the cells more sensitive to cisplatin. T… (full text at CIViC) PMID 23188704 · Ding et al., 2013 · Open in CIViC	civic
Thyroid Gland Papillary Carcinoma1
BIRC7 Amplification	(prognostic)	Prognostic	E	Supports Poor Outcome	3	submitted	EID8314 The results proposes a potential that BIRC7 represses PTC cell autophagy, causing increase in the migration and mtastatic ability of these cells PMID 32064154 · Liu et al., 2020 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.