Publication
An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (2)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 2
- geneGLIS2civic_curation1.00
- variantGLIS2 Fusioncivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 23153540
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| GLIS2 Fusion2 | ||||||||
| (prognostic) | Acute Megakaryoblastic LeukemiaALIAS | Prognostic | B | Supports Poor Outcome | 4 | submitted | EID8551The authors studied non-Down syndrome acute megakaryoblastic leukemia (non-DS-AMKL). Transcriptome sequencing was performed on diagnostic blasts from 14 patients. Validation cohort consisted of 34 ped… (full text at CIViC) PMID 23153540 · Gruber et al., 2012 · Open in CIViC | civic |
| (diagnostic) | Acute Myeloid Leukemia With CBFA2T3::GLIS2 FusionUNRESOLVED | Diagnostic | B | Supports Positive | 4 | accepted | EID11884In this 2012 study they included 14 patients diagnosed with non-down syndrome acute megakaryoblastic leukemia (AMKL), a subtype of pediatric acute myeloid leukemia (AML). Transcriptome sequencing was … (full text at CIViC) PMID 23153540 · Gruber et al., 2012 · Open in CIViC | civic |