Publication
A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice.
Authors not recorded
Cancer Res2012PMID 22440753stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerColon Carcinomacivic_curation1.00
- drugJW55civic_curation1.00
- geneAPCcivic_curation1.00
- variantAPC Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 22440753
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| APC Mutation1 | ||||||||
| JW55 | Colon Carcinoma | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID445Canonical Wnt signaling in colon carcinoma cells with APC mutation was inhibited by JW55 treatment. PMID 22440753 · Waaler et al., 2012 · Open in CIViC | civic |