APC Mutation

CI-VAR-00002645Explore in graph →CIViC 174

Curated evidence

Evidence by cancer (5 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–5 of 5 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Colon Carcinoma1
APC Mutation	JW55	Predictive	D	Supports Sensitivity Response	3	accepted	EID445 Canonical Wnt signaling in colon carcinoma cells with APC mutation was inhibited by JW55 treatment. PMID 22440753 · Waaler et al., 2012 · Open in CIViC	civic
Desmoid Fibromatosis1
APC Mutation OR CTNNB1 Activating Mutation	Nirogacestat	Predictive	A	Supports Sensitivity Response	2	submitted	EID12023 In a phase 3 trial (NCT03785964) involving 142 adults with progressing desmoid tumors, the gamma-secretase inhibitor nirogacestat demonstrated a significant progression-free survival benefit compared … (full text at CIViC) PMID 36884323 · Gounder et al., 2023 · Open in CIViC

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Malignant Colorectal Neoplasm3
APC Mutation	(prognostic)	Prognostic	C	Supports Poor Outcome	1	submitted	EID8038 While evidence from multiple clinical studies establishing a strong association between loss of function mutations in APC and response to 5-fluorouracil is lacking, some studies suggest APC mutations … (full text at CIViC) PMID 19307944 · Chen et al., 2009 · Open in CIViC	civic
APC Mutation	G007-LK	Predictive	D	Supports Sensitivity Response	4	accepted	EID446 G007-LK inhibits in vivo tumor growth in a subset of APC-mutant colorectal cancers xenograft models but may be limited by intestinal toxicity. PMID 23539443 · Lau et al., 2013 · Open in CIViC	civic
APC Mutation	Regorafenib	Predictive	B	Supports Sensitivity Response	2	submitted	EID13262 In a retrospective analysis of 76 patients with refractory metastatic colorectal cancer treated with regorafenib, APC mutations were detected in approximately 57% of tumors and were significantly asso… (full text at CIViC) PMID 33224274 · Lee et al., 2020 · Open in CIViC	civic