Publication

The impact of point mutations in the human androgen receptor: classification of mutations on the basis of transcriptional activity.

Authors not recorded

PLoS One2012PMID 22403669PMC3293822stubpubmedPublished

Abstract

Abstract (excerpt)

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Linked entities

Linked entities (2)

How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.

Validated 2

geneARcivic_curation1.00
variantAR R726Lcivic_curation1.00

Curated evidence

Evidence citing this paper (20)

civicCuratedShowing 1–20 of 20 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
AR A234T1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	3	submitted	EID10117 Missense mutations in AR found in prostate cancer with metastases or high Gleason score were selected for functional analysis. COS-7 cells were transfected with wild-type or mutant AR as well as a GRE… (full text at CIViC) PMID 22403669 · Hay et al., 2012 · Open in CIViC	civic
AR A748V1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	3	submitted	EID10128 Missense mutations in AR found in prostate cancer with metastases or high Gleason score were selected for functional analysis. COS-7 cells were transfected with wild-type or mutant AR as well as a GRE… (full text at CIViC) PMID 22403669 · Hay et al., 2012 · Open in CIViC	civic
AR A765T1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	3	submitted	EID10135 Missense mutations in AR found in prostate cancer with metastases or high Gleason score were selected for functional analysis. COS-7 cells were transfected with wild-type or mutant AR as well as a GRE… (full text at CIViC) PMID 22403669 · Hay et al., 2012 · Open in CIViC	civic
AR D221H1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	3	submitted	EID10115 Missense mutations in AR found in prostate cancer with metastases or high Gleason score were selected for functional analysis. COS-7 cells were transfected with wild-type or mutant AR as well as a GRE… (full text at CIViC) PMID 22403669 · Hay et al., 2012 · Open in CIViC	civic
AR D528G1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	3	submitted	EID10122 Missense mutations in AR found in prostate cancer with metastases or high Gleason score were selected for functional analysis. COS-7 cells were transfected with wild-type or mutant AR as well as a GRE… (full text at CIViC) PMID 22403669 · Hay et al., 2012 · Open in CIViC	civic
AR E198G1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	3	submitted	EID10116 Missense mutations in AR found in prostate cancer with metastases or high Gleason score were selected for functional analysis. COS-7 cells were transfected with wild-type or mutant AR as well as a GRE… (full text at CIViC) PMID 22403669 · Hay et al., 2012 · Open in CIViC	civic
AR K720E1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	3	submitted	EID10123 Missense mutations in AR found in prostate cancer with metastases or high Gleason score were selected for functional analysis. COS-7 cells were transfected with wild-type or mutant AR as well as a GRE… (full text at CIViC) PMID 22403669 · Hay et al., 2012 · Open in CIViC	civic
AR L57Q1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	3	submitted	EID10114 Missense mutations in AR found in prostate cancer with metastases or high Gleason score were selected for functional analysis. COS-7 cells were transfected with wild-type or mutant AR as well as a GRE… (full text at CIViC) PMID 22403669 · Hay et al., 2012 · Open in CIViC	civic
AR L744F1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	3	submitted	EID10127 Missense mutations in AR found in prostate cancer with metastases or high Gleason score were selected for functional analysis. COS-7 cells were transfected with wild-type or mutant AR as well as a GRE… (full text at CIViC) PMID 22403669 · Hay et al., 2012 · Open in CIViC	civic
AR N756D1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	3	submitted	EID10129 Missense mutations in AR found in prostate cancer with metastases or high Gleason score were selected for functional analysis. COS-7 cells were transfected with wild-type or mutant AR as well as a GRE… (full text at CIViC) PMID 22403669 · Hay et al., 2012 · Open in CIViC	civic
AR P340L1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	3	submitted	EID10120 Missense mutations in AR found in prostate cancer with metastases or high Gleason score were selected for functional analysis. COS-7 cells were transfected with wild-type or mutant AR as well as a GRE… (full text at CIViC) PMID 22403669 · Hay et al., 2012 · Open in CIViC	civic
AR P504L1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	3	submitted	EID10121 Missense mutations in AR found in prostate cancer with metastases or high Gleason score were selected for functional analysis. COS-7 cells were transfected with wild-type or mutant AR as well as a GRE… (full text at CIViC) PMID 22403669 · Hay et al., 2012 · Open in CIViC	civic
AR Q798E1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	3	submitted	EID10136 Missense mutations in AR found in prostate cancer with metastases or high Gleason score were selected for functional analysis. COS-7 cells were transfected with wild-type or mutant AR as well as a GRE… (full text at CIViC) PMID 22403669 · Hay et al., 2012 · Open in CIViC	civic
AR R726L1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	3	accepted	EID10126 Missense mutations in AR found in prostate cancer with metastases or high Gleason score were selected for functional analysis. COS-7 cells were transfected with wild-type or mutant AR as well as a GRE… (full text at CIViC) PMID 22403669 · Hay et al., 2012 · Open in CIViC	civic
AR S296R1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	3	submitted	EID10118 Missense mutations in AR found in prostate cancer with metastases or high Gleason score were selected for functional analysis. COS-7 cells were transfected with wild-type or mutant AR as well as a GRE… (full text at CIViC) PMID 22403669 · Hay et al., 2012 · Open in CIViC	civic
AR S334P1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	3	submitted	EID10119 Missense mutations in AR found in prostate cancer with metastases or high Gleason score were selected for functional analysis. COS-7 cells were transfected with wild-type or mutant AR as well as a GRE… (full text at CIViC) PMID 22403669 · Hay et al., 2012 · Open in CIViC	civic
AR S759P1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	3	submitted	EID10133 Missense mutations in AR found in prostate cancer with metastases or high Gleason score were selected for functional analysis. COS-7 cells were transfected with wild-type or mutant AR as well as a GRE… (full text at CIViC) PMID 22403669 · Hay et al., 2012 · Open in CIViC	civic
AR V757A1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	3	submitted	EID10131 Missense mutations in AR found in prostate cancer with metastases or high Gleason score were selected for functional analysis. COS-7 cells were transfected with wild-type or mutant AR as well as a GRE… (full text at CIViC) PMID 22403669 · Hay et al., 2012 · Open in CIViC	civic
AR V757I1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	3	submitted	EID10132 Missense mutations in AR found in prostate cancer with metastases or high Gleason score were selected for functional analysis. COS-7 cells were transfected with wild-type or mutant AR as well as a GRE… (full text at CIViC) PMID 22403669 · Hay et al., 2012 · Open in CIViC	civic
AR Y763C1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	3	submitted	EID10134 Missense mutations in AR found in prostate cancer with metastases or high Gleason score were selected for functional analysis. COS-7 cells were transfected with wild-type or mutant AR as well as a GRE… (full text at CIViC) PMID 22403669 · Hay et al., 2012 · Open in CIViC	civic