Publication
Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma.
Authors not recorded
Nat Genet2011PMID 22197931stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerMalignant Neoplasmcivic_curation1.00
- geneMAP2K1civic_curation1.00
- variantMAP2K1 P124Scivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 22197931
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| MAP2K1 P124S1 | ||||||||
| (oncogenic) | Malignant NeoplasmALIAS | Oncogenic | D | Supports Oncogenicity | 4 | accepted | EID12986MAP2K1 P124S was shown to constitutively activate ERK1/2 phosphorylation in the absence of serum in transiently transfected HEK293T cells (Fig 4a). In an NIH3T3 transformation assay (performed in trip… (full text at CIViC) PMID 22197931 · Nikolaev et al., 2011 · Open in CIViC | civic |