Publication
Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers.
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- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (7)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 7
- cancerGranulosa Cell Tumorcivic_curation1.00
- cancerOvarian Sertoli-Leydig Cell Tumorcivic_curation1.00
- geneDICER1civic_curation1.00
- variantDICER1 D1709Ecivic_curation1.00
- variantDICER1 D1709Gcivic_curation1.00
- variantDICER1 D1709Ncivic_curation1.00
- variantDICER1 E1813Qcivic_curation1.00
Curated evidence
Evidence citing this paper (17)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 22187960
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| DICER1 D1709G2 | ||||||||
| (oncogenic) | Granulosa Cell Tumor | Oncogenic | C | Supports Oncogenicity | 1 | accepted | EID5897DICER1 mutations in the RNase IIIb domain were found in 29% of nonepithelial ovarian tumors (n=103) with one mutation in a Juvenile ovarian granulosa-cell tumor (1/14; 7%). This individual had a somat… (full text at CIViC) PMID 22187960 · Heravi-Moussavi et al., 2012 · Open in CIViC | civic |
| (predisposing) | Ovarian Sertoli-Leydig Cell TumorALIAS | Predisposing | C | Supports Predisposition | 3 | accepted | EID5887DICER1 mutations in the RNase IIIb domain were found in 29% of nonepithelial ovarian tumors (n=103) with high predominance in Sertoli-Lydig cell tumors (26/43; 60%). There was one mutation in D1709G. PMID 22187960 · Heravi-Moussavi et al., 2012 · Open in CIViC | civic |
| DICER1 E1813 mutations1 | ||||||||
| (diagnostic) | Malignant Ovarian Neoplasm | Diagnostic | B | Supports Positive | 5 | rejected | EID7049E1813 residue has been described as a hotspot for somatic missense mutations in DICER1. PMID 22187960 · Heravi-Moussavi et al., 2012 · Open in CIViC | civic |
| DICER1 D1810Y2 | ||||||||
| (oncogenic) | Mature Ovarian TeratomaALIAS | Oncogenic | C | Supports Oncogenicity | 1 | submitted | EID5901DICER1 mutations in the RNase IIIb domain were found in 29% of nonepithelial ovarian tumors (n=103). Of the eight mature teratomas that were evaluated, one had a somatic mutation in D1810Y. PMID 22187960 · Heravi-Moussavi et al., 2012 · Open in CIViC | civic |
| 〃 | Ovarian Sertoli-Leydig Cell TumorALIAS | Oncogenic | C | Supports Oncogenicity | 1 | submitted | EID5890DICER1 mutations in the RNase IIIb domain were found in 29% of nonepithelial ovarian tumors (n=103) with high predominance in Sertoli-Lydig cell tumors (26/43; 60%).Two Sertoli-Lydig cell tumors harbo… (full text at CIViC) PMID 22187960 · Heravi-Moussavi et al., 2012 · Open in CIViC | civic |
| DICER1 D1709E2 | ||||||||
| (predisposing) | Ovarian Sertoli-Leydig Cell TumorALIAS | Predisposing | C | Supports Predisposition | 2 | accepted | EID5888DICER1 mutations in the RNase IIIb domain were found in 29% of nonepithelial ovarian tumors (n=103) with high predominance in Sertoli-Lydig cell tumors (26/43; 60%). There were two mutations in D1709E… (full text at CIViC) PMID 22187960 · Heravi-Moussavi et al., 2012 · Open in CIViC | civic |
| (oncogenic) | Glandular Pattern Ovarian Yolk Sac TumorUNRESOLVED | Oncogenic | C | Supports Oncogenicity | 1 | accepted | EID5900DICER1 mutations in the RNase IIIb domain were found in 29% of nonepithelial ovarian tumors (n=103). There was one Yolk sac tumor that had a somatic mutation in D1709E. PMID 22187960 · Heravi-Moussavi et al., 2012 · Open in CIViC | civic |
| DICER1 D1709N2 | ||||||||
| (predisposing) | Ovarian Sertoli-Leydig Cell TumorALIAS | Predisposing | B | Supports Predisposition | 3 | accepted | EID5886DICER1 mutations in the RNase IIIb domain were found in 29% of nonepithelial ovarian tumors (n=103) with high predominance in Sertoli-Lydig cell tumors (26/43; 60%). There were ten mutations in D1709N… (full text at CIViC) PMID 22187960 · Heravi-Moussavi et al., 2012 · Open in CIViC | civic |
| (oncogenic) | Glandular Pattern Ovarian Yolk Sac TumorUNRESOLVED | Oncogenic | C | Supports Oncogenicity | 1 | accepted | EID5899DICER1 mutations in the RNase IIIb domain were found in 29% of nonepithelial ovarian tumors (n=103). There was one Yolk sac tumor that had a somatic mutation in D1709N. PMID 22187960 · Heravi-Moussavi et al., 2012 · Open in CIViC | civic |
| DICER1 D1810H1 | ||||||||
| (predisposing) | Ovarian Sertoli-Leydig Cell TumorALIAS | Predisposing | C | Supports Predisposition | 2 | submitted | EID5889DICER1 mutations in the RNase IIIb domain were found in 29% of nonepithelial ovarian tumors (n=103) with high predominance in Sertoli-Lydig cell tumors (26/43; 60%). There was one mutation in D1810H. PMID 22187960 · Heravi-Moussavi et al., 2012 · Open in CIViC | civic |
| DICER1 D1810N1 | ||||||||
| (oncogenic) | Ovarian Sertoli-Leydig Cell TumorALIAS | Oncogenic | C | Supports Oncogenicity | 1 | submitted | EID5891DICER1 mutations in the RNase IIIb domain were found in 29% of nonepithelial ovarian tumors (n=103) with high predominance in Sertoli-Lydig cell tumors (26/43; 60%). There was one mutation in D1810N. PMID 22187960 · Heravi-Moussavi et al., 2012 · Open in CIViC | civic |
| DICER1 E1705K1 | ||||||||
| (predisposing) | Ovarian Sertoli-Leydig Cell TumorALIAS | Predisposing | B | Supports Predisposition | 3 | submitted | EID5885DICER1 mutations in the RNase IIIb domain were found in 29% of nonepithelial ovarian tumors (n=103) with high predominance in Sertoli-Lydig cell tumors (26/43; 60%). There were five mutations in E1705… (full text at CIViC) PMID 22187960 · Heravi-Moussavi et al., 2012 · Open in CIViC | civic |
| DICER1 E1813G1 | ||||||||
| (oncogenic) | Ovarian Sertoli-Leydig Cell TumorALIAS | Oncogenic | C | Supports Oncogenicity | 1 | submitted | EID5893DICER1 mutations in the RNase IIIb domain were found in 29% of nonepithelial ovarian tumors (n=103) with high predominance in Sertoli-Lydig cell tumors (26/43; 60%). There was one mutation in E1813G. PMID 22187960 · Heravi-Moussavi et al., 2012 · Open in CIViC | civic |
| DICER1 E1813K1 | ||||||||
| (oncogenic) | Ovarian Sertoli-Leydig Cell TumorALIAS | Oncogenic | C | Supports Oncogenicity | 1 | submitted | EID5894DICER1 mutations in the RNase IIIb domain were found in 29% of nonepithelial ovarian tumors (n=103) with high predominance in Sertoli-Lydig cell tumors (26/43; 60%). There was one mutation in E1813K. PMID 22187960 · Heravi-Moussavi et al., 2012 · Open in CIViC | civic |
| DICER1 E1813Q1 | ||||||||
| (oncogenic) | Ovarian Sertoli-Leydig Cell TumorALIAS | Oncogenic | C | Supports Oncogenicity | 1 | accepted | EID5892DICER1 mutations in the RNase IIIb domain were found in 29% of nonepithelial ovarian tumors (n=103) with high predominance in Sertoli-Lydig cell tumors (26/43; 60%). There were two patients with E1813… (full text at CIViC) PMID 22187960 · Heravi-Moussavi et al., 2012 · Open in CIViC | civic |
| DICER1 RNase IIIb Mutation2 | ||||||||
| (diagnostic) | Ovarian Sertoli-Leydig Cell TumorALIAS | Diagnostic | B | Supports Positive | 4 | submitted | EID13129A sequencing analysis of the DICER1 RNase IIIb region in nonepithelial ovarian neoplasms revealed a striking concentration of somatic mutations at residues required for metal binding within the cataly… (full text at CIViC) PMID 22187960 · Heravi-Moussavi et al., 2012 · Open in CIViC | civic |
| (oncogenic) | Ovarian Sertoli-Leydig Cell TumorALIAS | Oncogenic | D | Supports Oncogenicity | 4 | submitted | EID13130Somatic missense alterations repeatedly affecting the metal-coordinating residues of the DICER1 RNase IIIb domain, particularly E1705, D1709, D1810, and E1813, were found across nonepithelial ovarian … (full text at CIViC) PMID 22187960 · Heravi-Moussavi et al., 2012 · Open in CIViC | civic |