DICER1 D1810Y

CI-VAR-00000439Explore in graph →ENST00000526495.1:c.5428G>TCIViC 2198

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Mature Ovarian Teratoma1
DICER1 D1810Y	(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	submitted	EID5901 DICER1 mutations in the RNase IIIb domain were found in 29% of nonepithelial ovarian tumors (n=103). Of the eight mature teratomas that were evaluated, one had a somatic mutation in D1810Y. PMID 22187960 · Heravi-Moussavi et al., 2012 · Open in CIViC	civic
Ovarian Sertoli-Leydig Cell Tumor1
DICER1 D1810Y	(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	submitted	EID5890 DICER1 mutations in the RNase IIIb domain were found in 29% of nonepithelial ovarian tumors (n=103) with high predominance in Sertoli-Lydig cell tumors (26/43; 60%).Two Sertoli-Lydig cell tumors harbo… (full text at CIViC) PMID 22187960 · Heravi-Moussavi et al., 2012 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Pleuropulmonary Blastoma1
DICER1 D1810Y	(oncogenic)	Oncogenic	D	Supports Oncogenicity	2	submitted	EID6093 Sanger sequencing of several pleuropulmonary blastoma tumor lines showed possible somatic missense mutation, D1810Y, in DicerI. All mutations thought to be somatic were found in the RNase IIIb domain.… (full text at CIViC) PMID 24675358 · Seki et al., 2014 · Open in CIViC	civic