Publication
High prevalence of CIC fusion with double-homeobox (DUX4) transcription factors in EWSR1-negative undifferentiated small blue round cell sarcomas.
Authors not recorded
Genes Chromosomes Cancer2012PMID 22072439PMC3404826stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
No abstract stored. Read on PubMed
Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerCIC-Rearranged Sarcomacivic_curation1.00
- geneDUX4civic_curation1.00
- variantDUX4 Fusioncivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 22072439
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| DUX4 Fusion1 | ||||||||
| (diagnostic) | CIC-Rearranged Sarcoma | Diagnostic | B | Supports Positive | 3 | accepted | EID11595In this 2012 paper, 22 small blue round cell tumors that remained unclassified after screening for known sarcoma-related translocations, were analyzed for CIC and FUS rearrangements. 68% (15/22) were… (full text at CIViC) PMID 22072439 · Italiano et al., 2012 · Open in CIViC | civic |