Publication
Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias.
Authors not recorded
J Exp Med1990PMID 2175343PMC2188762stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerAcute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARAcivic_curation1.00
- geneRARAcivic_curation1.00
- variantRARA Fusioncivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 2175343
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| RARA Fusion1 | ||||||||
| (diagnostic) | Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARACURATED_BROADER | Diagnostic | B | Supports Positive | 4 | accepted | EID12334In this study, the authors investigated the role of retinoic acid receptor alpha (RARα) gene rearrangements in acute promyelocytic leukemia (APL), a distinct subtype of acute myeloid leukemia (AML) ch… (full text at CIViC) PMID 2175343 · Longo et al., 1990 · Open in CIViC | civic |